Nabumetone
Nabumetone Brand names, Nabumetone Analogs
Nabumetone Brand Names Mixture
- No information avaliable
Nabumetone Chemical_Formula
C15H16O2
Nabumetone RX_link
http://www.rxlist.com/cgi/generic/nabume.htm
Nabumetone fda sheet
Nabumetone msds (material safety sheet)
Nabumetone Synthesis Reference
No information avaliable
Nabumetone Molecular Weight
228.286 g/mol
Nabumetone Melting Point
No information avaliable
Nabumetone H2O Solubility
Practically insoluble
Nabumetone State
Solid
Nabumetone LogP
3.274
Nabumetone Dosage Forms
Tablets for oral administration (500 mg or 750 mg)
Nabumetone Indication
For acute and chronic treatment of signs and symptoms of osteoarthritis and rheumatoid arthritis.
Nabumetone Pharmacology
Nabumetone is a naphthylalkanone. It is a nonsteroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, analgesic and antipyretic properties in pharmacologic studies. As with other nonsteroidal anti-inflammatory agents, its mode of action is not known. However, the ability to inhibit prostaglandin synthesis may be involved in the anti-inflammatory effect.
Nabumetone Absorption
Well absorbed from the gastrointestinal tract. Coadministration of food increases the rate of absorption and subsequent appearance of 6MNA (the active metabolite) in the plasma but does not affect the extent of conversion of nabumetone into 6MNA.
Nabumetone side effects and Toxicity
The one overdose occurred in a 17-year-old female patient who had a history of abdominal pain and was hospitalized for increased abdominal pain following ingestion of 30 nabumetone tablets (15 grams total). Stools were negative for occult blood and there was no fall in serum hemoglobin concentration. The patient had no other symptoms.
Nabumetone Patient Information
Nabumetone Organisms Affected
Humans and other mammals
