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Metopyrone Brand names, Metopyrone Analogs

Metopyrone Brand Names Mixture

  • No information avaliable

Metopyrone Chemical_Formula


Metopyrone RX_link

Metopyrone fda sheet

Metopyrone FDA

Metopyrone msds (material safety sheet)

Metopyrone Synthesis Reference

No information avaliable

Metopyrone Molecular Weight

254.282 g/mol

Metopyrone Melting Point

200 to 203°C

Metopyrone H2O Solubility


Metopyrone State


Metopyrone LogP


Metopyrone Dosage Forms

2.5-mg and 5-mg tablets for oral administration

Metopyrone Indication

For the treatment of symptomatic orthostatic hypotension (OH).

Metopyrone Pharmacology

Midodrine is a prodrug, i.e., the therapeutic effect of orally administered midodrine is due to the major metabolite desglymidodrine formed by deglycination of midodrine. Desglymidodrine diffuses poorly across the blood-brain barrier, and is therefore not associated with effects on the central nervous system. Administration of midodrine results in a rise in standing, sitting, and supine systolic and diastolic blood pressure in patients with orthostatic hypotension of various etiologies. Standing systolic blood pressure is elevated by approximately 15 to 30 mmHg at 1 hour after a 10-mg dose of midodrine, with some effect persisting for 2 to 3 hours. Midodrine has no clinically significant effect on standing or supine pulse rates in patients with autonomic failure.

Metopyrone Absorption

Rapidly absorbed following oral administration. The absolute bioavailability of midodrine (measured as desglymidodrine) is 93% and is not affected by food.

Metopyrone side effects and Toxicity

Symptoms of overdose could include hypertension, piloerection (goosebumps), a sensation of coldness and urinary retention. The single doses that would be associated with symptoms of overdosage or would be potentially life- threatening are unknown. The oral LD50 is approximately 30 to 50 mg/kg in rats, 675 mg/kg in mice, and 125 to 160 mg/kg in dogs. Desglymidodrine is dialyzable.

Metopyrone Patient Information

No information avaliable

Metopyrone Organisms Affected

Humans and other mammals