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Methbipyranone Brand names, Methbipyranone Analogs

Methbipyranone Brand Names Mixture

  • No information avaliable

Methbipyranone Chemical_Formula


Methbipyranone RX_link

Methbipyranone fda sheet

Methbipyranone FDA

Methbipyranone msds (material safety sheet)

Methbipyranone Synthesis Reference

No information avaliable

Methbipyranone Molecular Weight

254.282 g/mol

Methbipyranone Melting Point

200 to 203°C

Methbipyranone H2O Solubility


Methbipyranone State


Methbipyranone LogP


Methbipyranone Dosage Forms

2.5-mg and 5-mg tablets for oral administration

Methbipyranone Indication

For the treatment of symptomatic orthostatic hypotension (OH).

Methbipyranone Pharmacology

Midodrine is a prodrug, i.e., the therapeutic effect of orally administered midodrine is due to the major metabolite desglymidodrine formed by deglycination of midodrine. Desglymidodrine diffuses poorly across the blood-brain barrier, and is therefore not associated with effects on the central nervous system. Administration of midodrine results in a rise in standing, sitting, and supine systolic and diastolic blood pressure in patients with orthostatic hypotension of various etiologies. Standing systolic blood pressure is elevated by approximately 15 to 30 mmHg at 1 hour after a 10-mg dose of midodrine, with some effect persisting for 2 to 3 hours. Midodrine has no clinically significant effect on standing or supine pulse rates in patients with autonomic failure.

Methbipyranone Absorption

Rapidly absorbed following oral administration. The absolute bioavailability of midodrine (measured as desglymidodrine) is 93% and is not affected by food.

Methbipyranone side effects and Toxicity

Symptoms of overdose could include hypertension, piloerection (goosebumps), a sensation of coldness and urinary retention. The single doses that would be associated with symptoms of overdosage or would be potentially life- threatening are unknown. The oral LD50 is approximately 30 to 50 mg/kg in rats, 675 mg/kg in mice, and 125 to 160 mg/kg in dogs. Desglymidodrine is dialyzable.

Methbipyranone Patient Information

No information avaliable

Methbipyranone Organisms Affected

Humans and other mammals