PharmacyCodes



Metirosine en es it fr

Metirosine Brand names, Metirosine Analogs

Metirosine Brand Names Mixture

  • No information avaliable

Metirosine Chemical_Formula

C8H17NO5

Metirosine RX_link

http://www.rxlist.com/cgi/generic2/miglitol.htm

Metirosine fda sheet

Metirosine msds (material safety sheet)

Metirosine Synthesis Reference

No information avaliable

Metirosine Molecular Weight

207.224 g/mol

Metirosine Melting Point

114 oC

Metirosine H2O Solubility

Soluble

Metirosine State

Solid

Metirosine LogP

-3.214

Metirosine Dosage Forms

Tablets (25 mg, 50 mg and 100 mg, for oral use)

Metirosine Indication

For use as an adjunct to diet to improve glycemic control in patients with non-insulin-dependent diabetes mellitus (NIDDM) whose hyperglycemia cannot be managed with diet alone.

Metirosine Pharmacology

Miglitol, an oral alpha-glucosidase inhibitor, is a desoxynojirimycin derivative that delays the digestion of ingested carbohydrates, thereby resulting in a smaller rise in blood glucose concentration following meals. As a consequence of plasma glucose reduction, miglitol reduce levels of glycosylated hemoglobin in patients with Type II (non-insulin-dependent) diabetes mellitus. Systemic nonenzymatic protein glycosylation, as reflected by levels of glycosylated hemoglobin, is a function of average blood glucose concentration over time. Because its mechanism of action is different, the effect of miglitol to enhance glycemic control is additive to that of sulfonylureas when used in combination. In addition, miglitol diminishes the insulinotropic and weight-increasing effects of sulfonylureas. Miglitol has minor inhibitory activity against lactase and consequently, at the recommended doses, would not be expected to induce lactose intolerance.

Metirosine Absorption

Absorption of miglitol is saturable at high doses with 25 mg being completely absorbed while a 100-mg dose is only 50-70% absorbed. No evidence exists to show that systemic absorption of miglitol adds to its therapeutic effect.

Metirosine side effects and Toxicity

Unlike sulfonylureas or insulin, an overdose will not result in hypoglycemia. An overdose may result in transient increases in flatulence, diarrhea, and abdomi-nal discomfort. Because of the lack of extra-intestinal effects seen with miglitol, no serious systemic reactions are expected in the event of an overdose.

Metirosine Patient Information

Metirosine Organisms Affected

Humans and other mammals