Methyltyrosine
Methyltyrosine Brand names, Methyltyrosine Analogs
Methyltyrosine Brand Names Mixture
- No information avaliable
Methyltyrosine Chemical_Formula
C8H17NO5
Methyltyrosine RX_link
http://www.rxlist.com/cgi/generic2/miglitol.htm
Methyltyrosine fda sheet
Methyltyrosine msds (material safety sheet)
Methyltyrosine Synthesis Reference
No information avaliable
Methyltyrosine Molecular Weight
207.224 g/mol
Methyltyrosine Melting Point
114 oC
Methyltyrosine H2O Solubility
Soluble
Methyltyrosine State
Solid
Methyltyrosine LogP
-3.214
Methyltyrosine Dosage Forms
Tablets (25 mg, 50 mg and 100 mg, for oral use)
Methyltyrosine Indication
For use as an adjunct to diet to improve glycemic control in patients with non-insulin-dependent diabetes mellitus (NIDDM) whose hyperglycemia cannot be managed with diet alone.
Methyltyrosine Pharmacology
Miglitol, an oral alpha-glucosidase inhibitor, is a desoxynojirimycin derivative that delays the digestion of ingested carbohydrates, thereby resulting in a smaller rise in blood glucose concentration following meals. As a consequence of plasma glucose reduction, miglitol reduce levels of glycosylated hemoglobin in patients with Type II (non-insulin-dependent) diabetes mellitus. Systemic nonenzymatic protein glycosylation, as reflected by levels of glycosylated hemoglobin, is a function of average blood glucose concentration over time. Because its mechanism of action is different, the effect of miglitol to enhance glycemic control is additive to that of sulfonylureas when used in combination. In addition, miglitol diminishes the insulinotropic and weight-increasing effects of sulfonylureas. Miglitol has minor inhibitory activity against lactase and consequently, at the recommended doses, would not be expected to induce lactose intolerance.
Methyltyrosine Absorption
Absorption of miglitol is saturable at high doses with 25 mg being completely absorbed while a 100-mg dose is only 50-70% absorbed. No evidence exists to show that systemic absorption of miglitol adds to its therapeutic effect.
Methyltyrosine side effects and Toxicity
Unlike sulfonylureas or insulin, an overdose will not result in hypoglycemia. An overdose may result in transient increases in flatulence, diarrhea, and abdomi-nal discomfort. Because of the lack of extra-intestinal effects seen with miglitol, no serious systemic reactions are expected in the event of an overdose.
Methyltyrosine Patient Information
Methyltyrosine Organisms Affected
Humans and other mammals
