Methionine
Brand names,
Methionine
Analogs
Methionine
Brand Names Mixture
Methionine
Chemical_Formula
C5H11N1O2S1
Methionine
RX_link
No information avaliable
Methionine
fda sheet
Methionine
msds (material safety sheet)
Methionine
Synthesis Reference
No information avaliable
Methionine
Molecular Weight
149.207 g/mol
Methionine
Melting Point
276-279 oC
Methionine
H2O Solubility
No information avaliable
Methionine
State
Solid
Methionine
LogP
-2.308
Methionine
Dosage Forms
Capsules, powder and tablets
Methionine
Indication
Used for protein synthesis including the formation of SAMe, L-homocysteine, L-cysteine, taurine, and sulfate.
Methionine
Pharmacology
Is a principle supplier of sulfur which prevents disorders of the hair, skin and nails; helps lower cholesterol levels by increasing the liver's production of lecithin; reduces liver fat and protects the kidneys; a natural chelating agent for heavy metals; regulates the formation of ammonia and creates ammonia-free urine which reduces bladder irritation; influences hair follicles and promotes hair growth. L-methionine may protect against the toxic effects of hepatotoxins, such as acetaminophen. Methionine may have antioxidant activity.
Methionine
Absorption
Absorbed from the lumen of the small intestine into the enterocytes by an active transport process.
Methionine
side effects and Toxicity
Doses of L-methionine of up to 250 mg daily are generally well tolerated. Higher doses may cause nausea, vomiting and headache. Healthy adults taking 8 grams of L-methionine daily for four days were found to have reduced serum folate levels and leucocytosis. Healthy adults taking 13.9 grams of L-methionine daily for five days were found to have changes in serum pH and potassium and increased urinary calcium excretion. Schizophrenic patients given 10 to 20 grams of L-methionine daily for two weeks developed functional psychoses. Single doses of 8 grams precipitated encephalopathy in patients with cirrhosis.
Methionine
Patient Information
There are no indications for the use of supplemental methionine unless specifically recommended by a physician. It is effective as an antidote in some cases of acetaminophen poisoning. But, because some research suggests that it may promote some cancers, its use as a supplement is inadvisable.
Methionine
Organisms Affected
Humans and other mammals