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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C12H22O11
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RX_link
http://www.rxlist.com/cgi/generic2/lactulose.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
342.296 g/mol
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Melting Point
173 - 178 oC
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H2O Solubility
764 mg/mL
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State
Solid
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LogP
-5.19
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Dosage Forms
Liquid; Powder; Solution; Syrup
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Indication
For the treatment of constipation and hepatic encephalopathy.
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Pharmacology
Therapeutically, lactulose has laxative and ammonia-detoxifying actions. In treating constipation lactulose metabolites draw water into the bowel, causing a cathartic effect through osmotic action.
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Absorption
Poorly absorbed from the gastrointestinal tract as no human enzyme that is capable of hydrolysis of this disaccharide is present in human gastrointestinal tissue.
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side effects and Toxicity
LD50=18.2 g/kg (oral, rat). Side effects include diarrhea and resultant dehydration.
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Patient Information
http://www.drugs.com/MTM/labetalol.html
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Organisms Affected
Humans and other mammals