Mazindolum [INN-Latin]
Mazindolum [INN-Latin] Brand names, Mazindolum [INN-Latin] Analogs
Mazindolum [INN-Latin] Brand Names Mixture
- For sope (sodium lauryl sulfate + stearic acid)
- Plax anti-plaque den rinse peppermint liq (sodium benzoate + sodium lauryl sulfate + sodium salicylate)
- Plax anti-plaque dent rinse soft mint liq (sodium benzoate + sodium lauryl sulfate + sodium salicylate)
- Plax anti-plaque dental rinse (sodium benzoate + sodium lauryl sulfate + sodium salicylate)
Mazindolum [INN-Latin] Chemical_Formula
C15H22N2O
Mazindolum [INN-Latin] RX_link
http://www.rxlist.com/cgi/generic2/mepivacaine.htm
Mazindolum [INN-Latin] fda sheet
Mazindolum [INN-Latin] msds (material safety sheet)
Mazindolum [INN-Latin] Synthesis Reference
No information avaliable
Mazindolum [INN-Latin] Molecular Weight
246.348 g/mol
Mazindolum [INN-Latin] Melting Point
150.5 oC
Mazindolum [INN-Latin] H2O Solubility
Soluble (7000 mg/L)
Mazindolum [INN-Latin] State
Solid
Mazindolum [INN-Latin] LogP
2.674
Mazindolum [INN-Latin] Dosage Forms
Liquid; Solution
Mazindolum [INN-Latin] Indication
For production of local or regional analgesia and anesthesia by local infiltration, peripheral nerve block techniques, and central neural techniques including epidural and caudal blocks.
Mazindolum [INN-Latin] Pharmacology
Mepivicaine is a local anesthetic of the amide type. Mepivicaine as a reasonably rapid onset and medium duration and is known by the proprietary names as Carbocaine and Polocaine. Mepivicaine is used in local infiltration and regional anesthesia. Systemic absorption of local anesthetics produces effects on the cardiovascular and central nervous systems. At blood concentrations achieved with normal therapeutic doses, changes in cardiac conduction, excitability, refractoriness, contractility, and peripheral vascular resistance are minimal.
Mazindolum [INN-Latin] Absorption
Absorbed locally. The rate of systemic absorption of local anesthetics is dependent upon the total dose and concentration of drug administered, the route of administration, the vascularity of the administration site, and the presence or absence of epinephrine in the anesthetic solution.
Mazindolum [INN-Latin] side effects and Toxicity
The mean seizure dosage of mepivacaine in rhesus monkeys was found to be 18.8 mg/kg with mean arterial plasma concentration of 24.4 µg/mL. The intravenous and subcutaneous LD 50 in mice is 23 mg/kg to 35 mg/kg and 280 mg/kg respectively.
Mazindolum [INN-Latin] Patient Information
Mazindolum [INN-Latin] Organisms Affected
Humans and other mammals
![Mazindolum_[INN-Latin]](/images/rx/APRD01094.gif)
