Marplan
Marplan Brand names, Marplan Analogs
Marplan Brand Names Mixture
- No information avaliable
Marplan Chemical_Formula
C12H13N3O2
Marplan RX_link
http://www.rxlist.com/cgi/generic/isocarbo.htm
Marplan fda sheet
Marplan msds (material safety sheet)
Marplan Synthesis Reference
No information avaliable
Marplan Molecular Weight
231.251 g/mol
Marplan Melting Point
105-106 oC
Marplan H2O Solubility
1600 mg/L
Marplan State
Solid
Marplan LogP
2.092
Marplan Dosage Forms
Tablet
Marplan Indication
Isocarboxazid is used to treat depression, especially when the patient is excitable or suffering from phobias (fears).
Marplan Pharmacology
Isocarboxazid is a non-selective hydrazine monoamine oxidase (MAO) inhibitor used to treat depression. In vivo and in vitro studies demonstrated inhibition of MAO in the brain, heart, and liver. Depression is a complicated disease that is not fully understood. It is thought that depression may be linked to an imbalance of chemicals within the brain. When depression occurs, there may be a decrease in the amount of chemicals released from nerve cells in the brain. These chemicals are called monoamines. Monoamines are broken down by a chemical called monoamine oxidase. Isocarboxazid prevents monoamine oxidase from breaking down the monoamines. This results in an increased amount of active monoamines in the brain. By increasing the amount of monoamines in the brain, the imbalance of chemicals thought to be caused by depression is altered. This helps relieve the symptoms of depression.
Marplan Absorption
Well absorbed from the gastrointestinal tract.
Marplan side effects and Toxicity
Signs of overdose include severe anxiety, confusion, convulsions, cool clammy skin, severe dizziness, severe drowsiness, fast and irregular pulse, fever, hallucinations, severe headache, high or low blood pressure, hyperactive reflexes, muscle stiffness, respiratory depression or failure, slowed reflexes, sweating, severe trouble in sleeping, and unusual irritability.
Marplan Patient Information
Marplan Organisms Affected
Humans and other mammals
