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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C12H13N3O2
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RX_link
http://www.rxlist.com/cgi/generic/isocarbo.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
231.251 g/mol
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Melting Point
105-106 oC
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H2O Solubility
1600 mg/L
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State
Solid
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LogP
2.092
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Dosage Forms
Tablet
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Indication
Isocarboxazid is used to treat depression, especially when the patient is excitable or suffering from phobias (fears).
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Pharmacology
Isocarboxazid is a non-selective hydrazine monoamine oxidase (MAO) inhibitor used to treat depression. In vivo and in vitro studies demonstrated inhibition of MAO in the brain, heart, and liver. Depression is a complicated disease that is not fully understood. It is thought that depression may be linked to an imbalance of chemicals within the brain. When depression occurs, there may be a decrease in the amount of chemicals released from nerve cells in the brain. These chemicals are called monoamines. Monoamines are broken down by a chemical called monoamine oxidase. Isocarboxazid prevents monoamine oxidase from breaking down the monoamines. This results in an increased amount of active monoamines in the brain. By increasing the amount of monoamines in the brain, the imbalance of chemicals thought to be caused by depression is altered. This helps relieve the symptoms of depression.
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Absorption
Well absorbed from the gastrointestinal tract.
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side effects and Toxicity
Signs of overdose include severe anxiety, confusion, convulsions, cool clammy skin, severe dizziness, severe drowsiness, fast and irregular pulse, fever, hallucinations, severe headache, high or low blood pressure, hyperactive reflexes, muscle stiffness, respiratory depression or failure, slowed reflexes, sweating, severe trouble in sleeping, and unusual irritability.
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Patient Information
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Organisms Affected
Humans and other mammals