MK 966 en es it fr

MK 966 Brand names, MK 966 Analogs

MK 966 Brand Names Mixture

  • No information avaliable

MK 966 Chemical_Formula


MK 966 RX_link

MK 966 fda sheet

MK_966 FDA

MK 966 msds (material safety sheet)

MK 966 Synthesis Reference

No information avaliable

MK 966 Molecular Weight

314.357 g/mol

MK 966 Melting Point

No information avaliable

MK 966 H2O Solubility


MK 966 State


MK 966 LogP


MK 966 Dosage Forms

Tablet (12.5 mg, 25 mg, or 50 mg); Oral suspension (12.5 or 25 mg per 5 mL solution)

MK 966 Indication

For the treatment of osteoarthritis, acute pain in adults and menstrual pain.

MK 966 Pharmacology

Rofecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is classified as a nonsteroidal anti-inflammatory drug (NSAID). Rofecoxib is used for its anti-inflammatory, analgesic, and antipyretic activities in the management of osteoarthritis (OA) and for the treatment of dysmenorrhea or acute pain. Unlike celecoxib, rofecoxib lacks a sulfonamide chain and does not require CYP450 enzymes for metabolism.

MK 966 Absorption

The mean oral bioavailability of rofecoxib at therapeutically recommended doses of 12.5, 25, and 50 mg is approximately 93%.

MK 966 side effects and Toxicity

No overdoses of rofecoxib were reported during clinical trials. Administration of single doses of rofecoxib 1000 mg to 6 healthy volunteers and multiple doses of 250 mg/day for 14 days to 75 healthy volunteers did not result in serious toxicity.

MK 966 Patient Information


Physicians should instruct their patients to read the patient package insert before starting therapy with VIOXX and to reread
it each time the prescription is renewed in case any information has changed.

VIOXX can cause discomfort and, rarely, more serious side effects, such as gastrointestinal bleeding, which may result in
hospitalization and even fatal outcomes. Although serious GI tract ulcerations and bleeding can occur without warning symptoms,
patients should be alert for the signs and symptoms of ulcerations and bleeding, and should ask for medical advice when observing
any indicative signs or symptoms. Patients should be apprised of the importance of this follow-up. Risk of GI Ulceration, Bleeding
and Perforation. Patients should be informed that VIOXX is not a substitute for aspirin for cardiovascular prophylaxis because of
its lack of effect on platelets. For additional cardiovascular safety information see CLINICAL STUDIES, Special Studies, VIGOR and
PRECAUTIONS, Cardiovascular Effects.

Patients should promptly report signs or symptoms of gastrointestinal ulceration or bleeding, skin rash, unexplained weight gain,
edema or chest pain to their physicians.

MK 966 Organisms Affected

Humans and other mammals