Lindane
Lindane Brand names, Lindane Analogs
Lindane Brand Names Mixture
- No information avaliable
Lindane Chemical_Formula
C6H6Cl6
Lindane RX_link
http://www.rxlist.com/cgi/generic2/lindane.htm
Lindane fda sheet
Lindane msds (material safety sheet)
Lindane Synthesis Reference
No information avaliable
Lindane Molecular Weight
290.828 g/mol
Lindane Melting Point
112.5 oC
Lindane H2O Solubility
7.3 mg/L
Lindane State
Liquid
Lindane LogP
3.834
Lindane Dosage Forms
Liquid; Lotion; Shampoo
Lindane Indication
For the treatment of patients infested with Sarcoptes scabiei (scabies or lice) who have either failed to respond to adequate doses, or are intolerant of other approved therapies.
Lindane Pharmacology
Scabies is a common, highly pruritic infestation of the skin caused by Sarcoptes scabiei (lice). It is a very contagious condition with specific lesions, such as burrows, and nonspecific lesions, such as papules, vesicles and excoriations. The typical areas of the body it affects are finger webs, scalp (hair), wrists, axillary folds, abdomen, buttocks, inframammary folds and genitalia (males). It is characterized by intense night-time itching. Scabies is spread through close personal contact (relatives, sexual partners, schoolchildren, chronically ill patients and crowded communities). Scabies infestations and the corresponding symptoms can be eliminated by killing the scabies with topical insecticides or scabicides. Lindane is a scabicide that is essentially and organochloride insecticide.
Lindane Absorption
Lindane is absorbed significantly through the skin. A mean peak blood concentration of 28 nanograms per mL occurred in infants and children 6 hours after total body application of lindane lotion for scabies.
Lindane side effects and Toxicity
Lindane is a moderately toxic compound via oral exposure, with a reported oral LD50 of 88 to 190 mg/kg in rats. Gamma-HCH (which constitutes 99% of lindane) is generally considered to be the most acutely toxic of the isomers following single administration. It is moderately toxic via the dermal route as well, with reported dermal LD50 values of 500 to 1000 mg/kg in rats, 300 mg/kg in mice, 400 mg/kg in guinea pigs, and 300 mg/kg in rabbits. Acute exposure to lindane may lead to central nervous system stimulation (usually developing within 1 hour), mental/motor impairment, excitation, clonic (intermittent) and tonic (continuous) convulsion. Other adverse reactions include central nervous system toxicity, as well as skin and gastrointestinal changes.
Lindane Patient Information
http://www.drugs.com/cons/Levocarnitine.html
Lindane Organisms Affected
Scabies (Sarcoptes scabei) and other insects
