Lamotrigine en es it fr

Lamotrigine Brand names, Lamotrigine Analogs

Lamotrigine Brand Names Mixture

  • No information avaliable

Lamotrigine Chemical_Formula


Lamotrigine RX_link

Lamotrigine fda sheet

Lamotrigine FDA

Lamotrigine msds (material safety sheet)

Lamotrigine MSDS

Lamotrigine Synthesis Reference

M. G. Baxter et al., Eur. pat. Appl. 21,121 (1981 to Wellcome Foundation); D. A. Sawyer et al., U.S. pat. 4,602,017 (1986)

Lamotrigine Molecular Weight

256.091 g/mol

Lamotrigine Melting Point

216-218 oC (uncorr)

Lamotrigine H2O Solubility

No information avaliable

Lamotrigine State


Lamotrigine LogP


Lamotrigine Dosage Forms

Tablet; Chewable

Lamotrigine Indication

For the adjunctive treatment of partial seizures in epilepsy and generalized seizures of Lennox-Gastaut syndrome; For the maintenance treatment of Bipolar I Disorder

Lamotrigine Pharmacology

Lamotrigine, an antiepileptic drug (AED) of the phenyltriazine class, is chemically unrelated to existing antiepileptic drugs. Lamotrigine is also used in the treatment of depression and bipolar disorder. Lamotrigine is thought to exert its anticonvulsant effect by stabilizing presynaptic neuronal membranes. Lamotrigine inhibits sodium currents by selectively binding to the inactivated state of the sodium channel and subsequently suppresses the release of the excilatory amino acid, glutamate.

Lamotrigine Absorption


Lamotrigine side effects and Toxicity

LD50=250 (mg/kg) (in rat, mice); LD50>640 orally (mg/kg) (in rat, mice) (Sawyer); Decreased level of consciousness, coma, delayed heartbeat, increased seizures, lack of coordination, rolling eyeballs

Lamotrigine Patient Information

Lamotrigine Organisms Affected

Humans and other mammals