Lamictal
Lamictal Brand names, Lamictal Analogs
Lamictal Brand Names Mixture
- No information avaliable
Lamictal Chemical_Formula
C9H7Cl2N5
Lamictal RX_link
http://www.rxlist.com/cgi/generic/lamotrigine.htm
Lamictal fda sheet
Lamictal msds (material safety sheet)
Lamictal Synthesis Reference
M. G. Baxter et al., Eur. pat. Appl. 21,121 (1981 to Wellcome Foundation); D. A. Sawyer et al., U.S. pat. 4,602,017 (1986)
Lamictal Molecular Weight
256.091 g/mol
Lamictal Melting Point
216-218 oC (uncorr)
Lamictal H2O Solubility
No information avaliable
Lamictal State
Solid
Lamictal LogP
1.497
Lamictal Dosage Forms
Tablet; Chewable
Lamictal Indication
For the adjunctive treatment of partial seizures in epilepsy and generalized seizures of Lennox-Gastaut syndrome; For the maintenance treatment of Bipolar I Disorder
Lamictal Pharmacology
Lamotrigine, an antiepileptic drug (AED) of the phenyltriazine class, is chemically unrelated to existing antiepileptic drugs. Lamotrigine is also used in the treatment of depression and bipolar disorder. Lamotrigine is thought to exert its anticonvulsant effect by stabilizing presynaptic neuronal membranes. Lamotrigine inhibits sodium currents by selectively binding to the inactivated state of the sodium channel and subsequently suppresses the release of the excilatory amino acid, glutamate.
Lamictal Absorption
98%
Lamictal side effects and Toxicity
LD50=250 (mg/kg) (in rat, mice); LD50>640 orally (mg/kg) (in rat, mice) (Sawyer); Decreased level of consciousness, coma, delayed heartbeat, increased seizures, lack of coordination, rolling eyeballs
Lamictal Patient Information
Lamictal Organisms Affected
Humans and other mammals
