Irressat
Irressat Brand names, Irressat Analogs
Irressat Brand Names Mixture
- No information avaliable
Irressat Chemical_Formula
C22H24ClFN4O3
Irressat RX_link
http://www.rxlist.com/cgi/generic3/iressa.htm
Irressat fda sheet
Irressat msds (material safety sheet)
Irressat Synthesis Reference
No information avaliable
Irressat Molecular Weight
446.902 g/mol
Irressat Melting Point
No information avaliable
Irressat H2O Solubility
Sparingly soluble (<pH4)
Irressat State
Solid
Irressat LogP
3.46
Irressat Dosage Forms
Tablet
Irressat Indication
For the continued treatment of patients with locally advanced or metastatic non-small cell lung cancer after failure of either platinum-based or docetaxel chemotherapies.
Irressat Pharmacology
Gefitinib inhibits the intracellular phosphorylation of numerous tyrosine kinases associated with transmembrane cell surface receptors, including the tyrosine kinases associated with the epidermal growth factor receptor (EGFR-TK). EGFR is expressed on the cell surface of many normal cells and cancer cells.
Irressat Absorption
Absorbed slowly after oral administration with mean bioavailability of 60%.
Irressat side effects and Toxicity
No information avaliable
Irressat Patient Information
Irressat Organisms Affected
Humans and other mammals
