Imatinib Methansulfonate
Imatinib Methansulfonate Brand names, Imatinib Methansulfonate Analogs
Imatinib Methansulfonate Brand Names Mixture
- No information avaliable
Imatinib Methansulfonate Chemical_Formula
C29H31N7O
Imatinib Methansulfonate RX_link
http://www.rxlist.com/cgi/generic3/gleevec.htm
Imatinib Methansulfonate fda sheet
Imatinib Methansulfonate msds (material safety sheet)
Imatinib Methansulfonate Synthesis Reference
No information avaliable
Imatinib Methansulfonate Molecular Weight
493.603 g/mol
Imatinib Methansulfonate Melting Point
226 oC (mesylate salt)
Imatinib Methansulfonate H2O Solubility
Very soluble in water at pH < 5.5 (mesylate salt)
Imatinib Methansulfonate State
Solid
Imatinib Methansulfonate LogP
3.218
Imatinib Methansulfonate Dosage Forms
Capsule; Tablet
Imatinib Methansulfonate Indication
For the treatment of newly diagnosed adult patients with Philadelphia chromosome positive chronic myeloid leukemia (CML). Also indicated for the treatment of pediatric patients with Ph+ chronic phase CML whose disease has recurred after stem cell transplant or who are resistant to interferon-alpha therapy. Also indicated with unresectable and/or metastatic malignant gastrointestinal stromal tumors (GIST).
Imatinib Methansulfonate Pharmacology
Imatinib is an antineoplastic agent used to treat chronic myelogenous leukemia. Imatinib is a 2-phenylaminopyrimidine derivative that functions as a specific inhibitor of a number of tyrosine kinase enzymes. In chronic myelogenous leukemia, the Philadelphia chromosome leads to a fusion protein of Abl with Bcr (breakpoint cluster region), termed Bcr-Abl. As this is now a continuously active tyrosine kinase, Imatinib is used to decrease Bcr-Abl activity.
Imatinib Methansulfonate Absorption
Imatinib is well absorbed with mean absolute bioavailability is 98% with maximum levels achieved within 2-4 hours of dosing
Imatinib Methansulfonate side effects and Toxicity
Side effects include nausea, vomiting, diarrhea, loss of appetite, dry skin, hair loss, swelling (especially in the legs or around the eyes) and muscle cramps
Imatinib Methansulfonate Patient Information
Imatinib Methansulfonate Organisms Affected
Humans and other mammals
