Glivec
Glivec Brand names, Glivec Analogs
Glivec Brand Names Mixture
- No information avaliable
Glivec Chemical_Formula
C29H31N7O
Glivec RX_link
http://www.rxlist.com/cgi/generic3/gleevec.htm
Glivec fda sheet
Glivec msds (material safety sheet)
Glivec Synthesis Reference
No information avaliable
Glivec Molecular Weight
493.603 g/mol
Glivec Melting Point
226 oC (mesylate salt)
Glivec H2O Solubility
Very soluble in water at pH < 5.5 (mesylate salt)
Glivec State
Solid
Glivec LogP
3.218
Glivec Dosage Forms
Capsule; Tablet
Glivec Indication
For the treatment of newly diagnosed adult patients with Philadelphia chromosome positive chronic myeloid leukemia (CML). Also indicated for the treatment of pediatric patients with Ph+ chronic phase CML whose disease has recurred after stem cell transplant or who are resistant to interferon-alpha therapy. Also indicated with unresectable and/or metastatic malignant gastrointestinal stromal tumors (GIST).
Glivec Pharmacology
Imatinib is an antineoplastic agent used to treat chronic myelogenous leukemia. Imatinib is a 2-phenylaminopyrimidine derivative that functions as a specific inhibitor of a number of tyrosine kinase enzymes. In chronic myelogenous leukemia, the Philadelphia chromosome leads to a fusion protein of Abl with Bcr (breakpoint cluster region), termed Bcr-Abl. As this is now a continuously active tyrosine kinase, Imatinib is used to decrease Bcr-Abl activity.
Glivec Absorption
Imatinib is well absorbed with mean absolute bioavailability is 98% with maximum levels achieved within 2-4 hours of dosing
Glivec side effects and Toxicity
Side effects include nausea, vomiting, diarrhea, loss of appetite, dry skin, hair loss, swelling (especially in the legs or around the eyes) and muscle cramps
Glivec Patient Information
Glivec Organisms Affected
Humans and other mammals
