IFN-gamma
IFN-gamma Brand names, IFN-gamma Analogs
IFN-gamma Brand Names Mixture
- No information avaliable
IFN-gamma Chemical_Formula
C761H1206N214O225S6
IFN-gamma RX_link
No information avaliable
IFN-gamma fda sheet
IFN-gamma msds (material safety sheet)
IFN-gamma Synthesis Reference
No information avaliable
IFN-gamma Molecular Weight
17145.6
IFN-gamma Melting Point
61 oC (Beldarrain, A. et al., Biochemistry 38:7865-7873 (1999))
IFN-gamma H2O Solubility
No information avaliable
IFN-gamma State
Liquid
IFN-gamma LogP
-0.823
IFN-gamma Dosage Forms
Solution (subcutaneous Injection)
IFN-gamma Indication
For treatment of Chronic granulomatous disease, Osteopetrosis
IFN-gamma Pharmacology
IFN gamma stimulates expression of the immunoglobulin heavy chain C gamma 3 and C gamma 2a germline transcripts in B cells. Many components of the antigen presentation pathways are also up-regulated by interferon gamma. It is also a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of type I interferons. Interferon gamma may also help the body regulate the activity of fibroblasts. By directly blocking the multiplication of fibroblasts and inhibiting the production and action of TGF-b, a potent scar-inducing molecule, Interferon gamma-1b may prevent excessive scarring.
IFN-gamma Absorption
No information avaliable
IFN-gamma side effects and Toxicity
No information avaliable
IFN-gamma Patient Information
No information avaliable
IFN-gamma Organisms Affected
No information avaliable
