Hydiphen
Hydiphen Brand names, Hydiphen Analogs
Hydiphen Brand Names Mixture
- No information avaliable
Hydiphen Chemical_Formula
C19H23ClN2
Hydiphen RX_link
http://www.rxlist.com/cgi/generic/clomipr.htm
Hydiphen fda sheet
Hydiphen msds (material safety sheet)
Hydiphen Synthesis Reference
No information avaliable
Hydiphen Molecular Weight
314.852 g/mol
Hydiphen Melting Point
189.5 oC
Hydiphen H2O Solubility
0.294 mg/L
Hydiphen State
Solid
Hydiphen LogP
4.803
Hydiphen Dosage Forms
Tablet
Hydiphen Indication
For the treatment of depression, obsessive compulsive disorder (OCD), panic attacks with or without agoraphobia, narcolepsy, chronic pain, and enuresis.
Hydiphen Pharmacology
Clomipramine, a tricyclic antidepressant, is the 3-chloro derivative of Imipramine. It was thought that tricylic antidepressants work exclusively by inhibiting the re-uptake of the neurotransmitters norepinephrine and serotonin by nerve cells. However, this response occurs immediately, yet mood does not lift for around two weeks. It is now thought that changes occur in receptor sensitivity in the cerebral cortex and hippocampus. The hippocampus is part of the limbic system, a part of the brain involved in emotions. Presynaptic receptors are affected: alpha-1 and beta-1 receptors are sensitized, alpha-2 receptors are desensitized (leading to increased noradrenaline production). Tricyclics are also known as effective analgesics for different types of pain, especially neuropathic or neuralgic pain.
Hydiphen Absorption
Bioavailability is approximately 50% orally.
Hydiphen side effects and Toxicity
Signs and symptoms vary in severity depending upon factors such as the amount of drug absorbed, the age of the patient, and the time elapsed since drug ingestion. Critical manifestations of overdose include cardiac dysrhythmias, severe hypotension, convulsions, and CNS depression including coma. Changes in the electrocardiogram, particularly in QRS axis or width, are clinically significant indicators of tricyclic toxicity. In U.S. clinical trials, 2 deaths occurred in 12 reported cases of acute overdosage with Anafranil either alone or in combination with other drugs. One death involved a patient suspected of ingesting a dose of 7000 mg. The second death involved a patient suspected of ingesting a dose of 5750 mg.
Hydiphen Patient Information
Prescribers or other health professionals should inform patients, their families, and their caregivers about the benefits and risks associated with treatment with clomipramine hydrochloride and should counsel them in its appropriate use. A patient Medication Guide About Using Antidepressants in Children and Teenagers is available for clomipramine hydrochloride. The prescriber or health professional should instruct patients, their families, and their caregivers to read the Medication Guide and should assist them in understanding its contents. Patients should be given the opportunity to discuss the contents of the Medication Guide and to obtain answers to any questions they may have.
Hydiphen Organisms Affected
Humans and other mammals
