Clomipramine HCL
Clomipramine HCL Brand names, Clomipramine HCL Analogs
Clomipramine HCL Brand Names Mixture
- No information avaliable
Clomipramine HCL Chemical_Formula
C19H23ClN2
Clomipramine HCL RX_link
http://www.rxlist.com/cgi/generic/clomipr.htm
Clomipramine HCL fda sheet
Clomipramine HCL msds (material safety sheet)
Clomipramine HCL Synthesis Reference
No information avaliable
Clomipramine HCL Molecular Weight
314.852 g/mol
Clomipramine HCL Melting Point
189.5 oC
Clomipramine HCL H2O Solubility
0.294 mg/L
Clomipramine HCL State
Solid
Clomipramine HCL LogP
4.803
Clomipramine HCL Dosage Forms
Tablet
Clomipramine HCL Indication
For the treatment of depression, obsessive compulsive disorder (OCD), panic attacks with or without agoraphobia, narcolepsy, chronic pain, and enuresis.
Clomipramine HCL Pharmacology
Clomipramine, a tricyclic antidepressant, is the 3-chloro derivative of Imipramine. It was thought that tricylic antidepressants work exclusively by inhibiting the re-uptake of the neurotransmitters norepinephrine and serotonin by nerve cells. However, this response occurs immediately, yet mood does not lift for around two weeks. It is now thought that changes occur in receptor sensitivity in the cerebral cortex and hippocampus. The hippocampus is part of the limbic system, a part of the brain involved in emotions. Presynaptic receptors are affected: alpha-1 and beta-1 receptors are sensitized, alpha-2 receptors are desensitized (leading to increased noradrenaline production). Tricyclics are also known as effective analgesics for different types of pain, especially neuropathic or neuralgic pain.
Clomipramine HCL Absorption
Bioavailability is approximately 50% orally.
Clomipramine HCL side effects and Toxicity
Signs and symptoms vary in severity depending upon factors such as the amount of drug absorbed, the age of the patient, and the time elapsed since drug ingestion. Critical manifestations of overdose include cardiac dysrhythmias, severe hypotension, convulsions, and CNS depression including coma. Changes in the electrocardiogram, particularly in QRS axis or width, are clinically significant indicators of tricyclic toxicity. In U.S. clinical trials, 2 deaths occurred in 12 reported cases of acute overdosage with Anafranil either alone or in combination with other drugs. One death involved a patient suspected of ingesting a dose of 7000 mg. The second death involved a patient suspected of ingesting a dose of 5750 mg.
Clomipramine HCL Patient Information
Prescribers or other health professionals should inform patients, their families, and their caregivers about the benefits and risks associated with treatment with clomipramine hydrochloride and should counsel them in its appropriate use. A patient Medication Guide About Using Antidepressants in Children and Teenagers is available for clomipramine hydrochloride. The prescriber or health professional should instruct patients, their families, and their caregivers to read the Medication Guide and should assist them in understanding its contents. Patients should be given the opportunity to discuss the contents of the Medication Guide and to obtain answers to any questions they may have.
Clomipramine HCL Organisms Affected
Humans and other mammals
