Hexafluorenium
Hexafluorenium Brand names, Hexafluorenium Analogs
Hexafluorenium Brand Names Mixture
- No information avaliable
Hexafluorenium Chemical_Formula
C36H42Br2N2
Hexafluorenium RX_link
No information avaliable
Hexafluorenium fda sheet
Hexafluorenium msds (material safety sheet)
Hexafluorenium Synthesis Reference
No information avaliable
Hexafluorenium Molecular Weight
662.54 g/mol
Hexafluorenium Melting Point
153.5 oC
Hexafluorenium H2O Solubility
No information avaliable
Hexafluorenium State
Solid
Hexafluorenium LogP
-0.06
Hexafluorenium Dosage Forms
Solution (injectable)
Hexafluorenium Indication
Used as an adjunct with succinylcholine (or suxamethonium chloride) to prolong muscle relaxation and to prevent succinylcholine-induced muscle fasciculations.
Hexafluorenium Pharmacology
Hexafluorenium is a cholinesterase antagonist that can be used to prolong the relaxation effects of succinylcholine or suxamethonium chloride. Suxamethonium acts as a depolarizing muscle relaxant. It imitates the action of acetylcholine at the neuromuscular junction and is degraded by pseudocholinesterase, a plasma cholinesterase. The prolonged stimulation of the acetylcholine receptor results first in disorganized muscle contractions, then in profound relaxation. Cholinesterases catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid, a reaction necessary to allow a cholinergic neuron to return to its resting state after activation. There are two types of cholinesterase acetylcholinesterase and pseuodocholinesterase. The first hydrolyses acetylcholine more quickly; the latter hydrolyses butyrylcholine and succinylcholine more quickly. An absence or mutation of the pseudocholinesterase enzyme leads to a medical condition known simply as pseudocholinesterase deficiency. This is a silent condition that only manifests itself when people who have the deficiency receive the muscle relaxants succinylcholine or mivacurium during a surgery.
Hexafluorenium Absorption
No information avaliable
Hexafluorenium side effects and Toxicity
LD50 = 280 mg/kg (mouse, oral)
Hexafluorenium Patient Information
No information avaliable
Hexafluorenium Organisms Affected
Humans and other mammals
