PharmacyCodes



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HMS Brand names, HMS Analogs

HMS Brand Names Mixture

  • No information avaliable

HMS Chemical_Formula

C17H25N3O5S

HMS RX_link

http://www.rxlist.com/cgi/generic2/meropen.htm

HMS fda sheet

HMS FDA

HMS msds (material safety sheet)

HMS Synthesis Reference

No information avaliable

HMS Molecular Weight

383.464 g/mol

HMS Melting Point

No information avaliable

HMS H2O Solubility

Sparingly

HMS State

Solid

HMS LogP

0.33

HMS Dosage Forms

Powder for solution (for injection)

HMS Indication

For use as single agent therapy for the treatment of the following infections when caused by susceptible isolates of the designated microorganisms: complicated skin and skin structure infections due to Staphylococcus aureus (b-lactamase and non-b-lactamase producing, methicillin-susceptible isolates only), Streptococcus pyogenes, Streptococcus agalactiae, viridans group streptococci, Enterococcus faecalis (excluding vancomycin-resistant isolates), Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis, Bacteroides fragilis and Peptostreptococcus species; complicated appendicitis and peritonitis caused by viridans group streptococci, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacteroides fragilis, B. thetaiotaomicron, and Peptostreptococcus species. Also for use in the treatment of bacterial meningitis caused by Streptococcus pneumoniae, Haemophilus influenzae (b-lactamase and non-b-lactamase-producing isolates), and Neisseria meningitidis.

HMS Pharmacology

Meropenem is a broad-spectrum carbapenem antibiotic. It is active against Gram-positive and Gram-negative bacteria. Meropenem exerts its action by penetrating bacterial cells readily and interfering with the synthesis of vital cell wall components, which leads to cell death.

HMS Absorption

No information avaliable

HMS side effects and Toxicity

In mice and rats, large intravenous doses of meropenem (2200-4000 mg/kg) have been associated with ataxia, dyspnea, convulsions, and mortalities.

HMS Patient Information

HMS Organisms Affected

Enteric bacteria and other eubacteria