Gentamcin Sulfate

Gentamcin Sulfate Brand names, Gentamcin Sulfate Analogs

Gentamcin Sulfate Brand Names Mixture

Diprogen Crm (Betamethasone Dipropionate + Gentamicin Sulfate)
Diprogen Ont (Betamethasone Dipropionate + Gentamicin Sulfate)
Garasone Oph/Ot Sol (Betamethasone + Gentamicin Sulfate)
Garasone Ophthalmic Ointment (Betamethasone + Gentamicin Sulfate)
Gentamicin Sulfate in Nacl 0.9% Inj (Gentamicin Sulfate + Sodium Chloride)
Gentamicin Sulfate in Nacl 0.9% Inj (Gentamicin Sulfate + Sodium Chloride)
Gentocin Durafilm (Betamethasone 21-Acetate + Gentamicin Sulfate)
Gentocin Otic Solution (Betamethasone + Gentamicin Sulfate)
Otomax Ointment (Betamethasone + Clotrimazole + Gentamicin Sulfate)
Sandoz Pentasone (Betamethasone + Gentamicin Sulfate)
Topagen Ont (Betamethasone + Gentamicin Sulfate)
Topagen Spray (Betamethasone + Gentamicin Sulfate)
Valisone G Cream (Betamethasone + Gentamicin Sulfate)
Valisone G Ointment (Betamethasone + Gentamicin Sulfate)

Gentamcin Sulfate Chemical_Formula

C₂₁H₄₃N₅O₇

Gentamcin Sulfate RX_link

http://www.rxlist.com/cgi/generic2/pedgenta.htm

Gentamcin Sulfate fda sheet

Gentamcin Sulfate msds (material safety sheet)

Gentamcin_Sulfate MSDS

Gentamcin Sulfate Synthesis Reference

No information avaliable

Gentamcin Sulfate Molecular Weight

477.596 g/mol

Gentamcin Sulfate Melting Point

105°C (218-237°C as sulfate salt)

Gentamcin Sulfate H₂O Solubility

100 mg/mL

Gentamcin Sulfate State

Solid

Gentamcin Sulfate LogP

-3.637

Gentamcin Sulfate Dosage Forms

Cream; Drops; Liquid; Ointment; Solution

Gentamcin Sulfate Indication

For treatment of serious infections caused by susceptible strains of the following microorganisms: P. aeruginosa, Proteus species (indole-positive and indole-negative), E. coli, Klebsiella-Enterobactor-Serratia species, Citrobacter species and Staphylococcus species (coagulase-positive and coagulase-negative).

Gentamcin Sulfate Pharmacology

Gentamicin is a broad spectrum aminoglycoside antibiotic. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit, causing misreading of t-RNA, leaving the bacterium unable to synthesize proteins vital to its growth. Aminoglycosides are useful primarily in infections involving aerobic, Gram-negative bacteria, such as Pseudomonas, Acinetobacter, and Enterobacter. In addition, some mycobacteria, including the bacteria that cause tuberculosis, are susceptible to aminoglycosides. Infections caused by Gram-positive bacteria can also be treated with aminoglycosides, but other types of antibiotics are more potent and less damaging to the host. In the past the aminoglycosides have been used in conjunction with penicillin-related antibiotics in streptococcal infections for their synergistic effects, particularly in endocarditis. Aminoglycosides are mostly ineffective against anaerobic bacteria, fungi and viruses.

Gentamcin Sulfate Absorption

Injections lead to peak serum concentrations in 30-60 minutes. Topical gentamicin is readily absorbed from large burned, denuded, or granulating areas but not through intact skin. Absorption of gentamicin is faster and greater with the cream compared to the ointment. Gentamicin is absorbed in small quantities following topical application to the eye. Gentamicin is also absorbed in small amounts following topical application to the ear (especially if the eardrum is perforated or if tissue damage is present).

Gentamcin Sulfate side effects and Toxicity

Mouse, intravenous LD₅₀: 52 mg/kg; rat, intravenous LD₅₀: 96 mg/kg.

Gentamcin Sulfate Patient Information