Felbamyl
Brand names,
Felbamyl
Analogs
Felbamyl
Brand Names Mixture
Felbamyl
Chemical_Formula
C11H14N2O4
Felbamyl
RX_link
http://www.rxlist.com/cgi/generic3/felbamate.htm
Felbamyl
fda sheet
Felbamyl
msds (material safety sheet)
Felbamyl
Synthesis Reference
No information avaliable
Felbamyl
Molecular Weight
238.24 g/mol
Felbamyl
Melting Point
151.5 oC
Felbamyl
H2O Solubility
Slightly soluble in water
Felbamyl
State
Solid
Felbamyl
LogP
0.76
Felbamyl
Dosage Forms
Tablet; Suspension
Felbamyl
Indication
For use only in those patients who respond inadequately to alternative treatments and whose epilepsy is so severe that a substantial risk of aplastic anemia and/or liver failure is deemed acceptable in light of the benefits conferred by its use.
Felbamyl
Pharmacology
Felbamate is an antiepileptic indicated as monotherapy or as an adjunct to other anticonvulsants for the treatment of partial seizures resulting from epilepsy. Receptor-binding studies in vitro indicate that felbamate has weak inhibitory effects on GABA-receptor binding, benzodiazepine receptor binding, and is devoid of activity at the MK-801 receptor binding site of the NMDA receptor-ionophore complex. However, felbamate does interact as an antagonist at the strychnine-insensitive glycine recognition site of the NMDA receptor-ionophore complex.
Felbamyl
Absorption
>90%
Felbamyl
side effects and Toxicity
LD50=5000 mg/kg (Orally in rats)
Felbamyl
Patient Information
Patient Information:
Felmabate can cause severe blood abnormality, hepatic failure and other fatal
conditions. Talk about the risks and side effects with your doctor before taking it.
Do not stop the medication without consulting your doctor. Finish the medication
even if you feel better.
Felbamyl
Organisms Affected
Humans and other mammals