PharmacyCodes



Ezetimibe [Usan] en es it fr

Ezetimibe [Usan] Brand names, Ezetimibe [Usan] Analogs

Ezetimibe [Usan] Brand Names Mixture

  • No information avaliable

Ezetimibe [Usan] Chemical_Formula

C24H21F2NO3

Ezetimibe [Usan] RX_link

http://www.rxlist.com/cgi/generic/ezetimibe.htm

Ezetimibe [Usan] fda sheet

Ezetimibe_[Usan] FDA

Ezetimibe [Usan] msds (material safety sheet)

Ezetimibe [Usan] Synthesis Reference

No information avaliable

Ezetimibe [Usan] Molecular Weight

409.425 g/mol

Ezetimibe [Usan] Melting Point

No information avaliable

Ezetimibe [Usan] H2O Solubility

No information avaliable

Ezetimibe [Usan] State

Solid

Ezetimibe [Usan] LogP

4.584

Ezetimibe [Usan] Dosage Forms

Tablet

Ezetimibe [Usan] Indication

For use as adjunctive therapy to diet for the reduction of elevated total-C, LDL-C, and Apo B in patients with primary (heterozygous familial and non-familial) hypercholesterolemia.

Ezetimibe [Usan] Pharmacology

Ezetimibe is in a class of lipid-lowering compounds that selectively inhibits the intestinal absorption of cholesterol and related phytosterols. Ezetimibe, administered alone is indicated as adjunctive therapy to diet for the reduction of elevated total-C, LDL-C, and Apo B in patients with primary (heterozygous familial and non-familial) hypercholesterolemia. It is also used in combination therapy with HMG-CoA reductase inhibitors. Ezetimibe has a mechanism of action that differs from those of other classes of cholesterol-reducing compounds (HMG-CoA reductase inhibitors, bile acid sequestrants, fibric acid derivatives, and plant stanols). Ezetimibe does not inhibit cholesterol synthesis in the liver, or increase bile acid excretion but instead localizes and appears to act at the brush border of the small intestine and inhibits the absorption of cholesterol, leading to a decrease in the delivery of intestinal cholesterol to the liver. This causes a reduction of hepatic cholesterol stores and an increase in clearance of cholesterol from the blood; this distinct mechanism is complementary to that of HMG-CoA reductase inhibitors.

Ezetimibe [Usan] Absorption

No information avaliable

Ezetimibe [Usan] side effects and Toxicity

No information avaliable

Ezetimibe [Usan] Patient Information

No information avaliable

Ezetimibe [Usan] Organisms Affected

Humans and other mammals