Ethotoine [INN-French] en es it fr

Ethotoine [INN-French] Brand names, Ethotoine [INN-French] Analogs

Ethotoine [INN-French] Brand Names Mixture

  • No information avaliable

Ethotoine [INN-French] Chemical_Formula


Ethotoine [INN-French] RX_link

Ethotoine [INN-French] fda sheet

Ethotoine [INN-French] msds (material safety sheet)

Ethotoine [INN-French] Synthesis Reference

No information avaliable

Ethotoine [INN-French] Molecular Weight

242.27 g/mol

Ethotoine [INN-French] Melting Point

No information avaliable

Ethotoine [INN-French] H2O Solubility

Slight (calcium salt)

Ethotoine [INN-French] State


Ethotoine [INN-French] LogP


Ethotoine [INN-French] Dosage Forms

Capsules (200, 300 mg); Tablets (600 mg)

Ethotoine [INN-French] Indication

For relief of the signs and symptoms of rheumatoid arthritis and osteoarthritis. Also for the relief of mild to moderate pain.

Ethotoine [INN-French] Pharmacology

Fenoprofen is a propionic acid derivative with analgesic, antiinflammatory and antipyretic properties. Fenoprofen inhibits prostaglandin synthesis by decreasing the enzyme needed for biosynthesis. In patients with rheumatoid arthritis, the anti-inflammatory action of fenoprofen has been evidenced by relief of pain, increase in grip strength, and reductions in joint swelling, duration of morning stiffness, and disease activity (as assessed by both the investigator and the patient). In patients with osteoarthritis, the anti-inflammatory and analgesic effects of fenoprofen have been demonstrated by reduction in tenderness as a response to pressure and reductions in night pain, stiffness, swelling, and overall disease activity (as assessed by both the patient and the investigator). These effects have also been demonstrated by relief of pain with motion and at rest and increased range of motion in involved joints. In patients with rheumatoid arthritis and osteoarthritis, clinical studies have shown fenoprofen to be comparable to aspirin in controlling the aforementioned measures of disease activity, but mild gastrointestinal reactions (nausea, dyspepsia) and tinnitus occurred less frequently in patients treated with fenoprofen than in aspirin-treated patients. It is not known whether fenoprofen causes less peptic ulceration than does aspirin. In patients with pain, the analgesic action of fenoprofen has produced a reduction in pain intensity, an increase in pain relief, improvement in total analgesia scores, and a sustained analgesic effect.

Ethotoine [INN-French] Absorption

Rapidly absorbed under fasting conditions, and peak plasma levels of 50 µg/mL are achieved within 2 hours after oral administration of 600 mg doses.

Ethotoine [INN-French] side effects and Toxicity

Symptoms of overdose appear within several hours and generally involve the gastrointestinal and central nervous systems. They include dyspepsia, nausea, vomiting, abdominal pain, dizziness, headache, ataxia, tinnitus, tremor, drowsiness, and confusion. Hyperpyrexia, tachycardia, hypotension, and acute renal failure may occur rarely following overdose. Respiratory depression and metabolic acidosis have also been reported following overdose with certain NSAIDs.

Ethotoine [INN-French] Patient Information

No information avaliable

Ethotoine [INN-French] Organisms Affected

Humans and other mammals