Eposin

Eposin Brand names, Eposin Analogs

Eposin Brand Names Mixture

No information avaliable

Eposin Chemical_Formula

C₂₉H₃₂O₁₃

Eposin RX_link

http://www.rxlist.com/cgi/generic2/etopophos.htm

Eposin fda sheet

http://www.accessdata.fda.gov/scripts/cder/onctools/labels.cfm?GN=etoposide,%20VP-16

Eposin msds (material safety sheet)

Eposin MSDS

Eposin Synthesis Reference

No information avaliable

Eposin Molecular Weight

588.557 g/mol

Eposin Melting Point

236-251 ^oC

Eposin H₂O Solubility

58.7 mg/L

Eposin State

Solid

Eposin LogP

1.197

Eposin Dosage Forms

Solution; Capsule; Liquid

Eposin Indication

For use in combination with other chemotherapeutic agents in the treatment of refractory testicular tumors and as first line treatment in patients with small cell lung cancer. Also used to treat other malignancies such as lymphoma, non-lymphocytic leukemia, and glioblastoma multiforme.

Eposin Pharmacology

Etoposide is an antineoplastic agent and an epipodophyllotoxin (a semisynthetic derivative of the podophyllotoxins). It inhibits DNA topoisomerase II, thereby inhibiting DNA synthesis. Etoposide is cell cycle dependent and phase specific, affecting mainly the S and G2 phases. Two different dose-dependent responses are seen. At high concentrations (10 µg/mL or more), lysis of cells entering mitosis is observed. At low concentrations (0.3 to 10 µg/mL), cells are inhibited from entering prophase. It does not interfere with microtubular assembly. The predominant macromolecular effect of etoposide appears to be the induction of DNA strand breaks by an interaction with DNA-topoisomerase II or the formation of free radicals.

Eposin Absorption

Absorbed well, time to peak plasma concentration is 1-1.5 hrs. Mean bioavailability is 50%.

Eposin side effects and Toxicity

Side effects include alopecia, constipation, diarrhea, nausea and vomiting and secondary malignancies (leukemia).

Eposin Patient Information

Patients are generally advised to call their doctor in case of fever, symptoms of infection or painful injection sites, as these may progress severely without adequate medical attention. It is advised to drink lots of fluids after treatment to prevent damage to the bladder and kidneys, typically 1.5 to 3.5 litres of water on the day of treatment and for several days after.

Eposin Organisms Affected

Humans and other mammals