Elspar (Merck
Brand names,
Elspar (Merck
Analogs
Elspar (Merck
Brand Names Mixture
Elspar (Merck
Chemical_Formula
C1377H2208N382O442S17
Elspar (Merck
RX_link
http://www.rxlist.com/cgi/generic3/asparaginase.htm
Elspar (Merck
fda sheet
Elspar (Merck
msds (material safety sheet)
Elspar (Merck
Synthesis Reference
No information avaliable
Elspar (Merck
Molecular Weight
31731.9
Elspar (Merck
Melting Point
No information avaliable
Elspar (Merck
H2O Solubility
No information avaliable
Elspar (Merck
State
Liquid
Elspar (Merck
LogP
0.059
Elspar (Merck
Dosage Forms
Powder for solution; Solution (IV or IM injection)
Elspar (Merck
Indication
For treatment of acute lympocytic leukemia and non-Hodgkins lymphoma
Elspar (Merck
Pharmacology
In a significant number of patients with acute leukemia, the malignant cells are dependent on an exogenous source of asparagine for survival. Normal cells, however, are able to synthesize asparagine and thus are affected less by the rapid depletion produced by treatment with the enzyme asparaginase. Elspar exploits a metabolic defect in asparagine synthesis of some malignant cells.
Elspar (Merck
Absorption
No information avaliable
Elspar (Merck
side effects and Toxicity
No information avaliable
Elspar (Merck
Patient Information
No information avaliable
Elspar (Merck
Organisms Affected
Humans and other mammals