Ellence
Ellence Brand names, Ellence Analogs
- 4'-Epiadriamycin
- 4'-Epidoxorubicin
- Ellence
- Epi-Dx
- Epiadriamycin
- Epidoxorubicin
- Epirubicina [Inn-Spanish]
- Epirubicina [Spanish]
- Epirubicine [French]
- Epirubicine [Inn-French]
- Epirubicinum [Inn-Latin]
- Epirubicinum [Latin]
- IMI 28
- Pharmorubicin Pfs
- Pidorubicina [Inn-Spanish]
- Pidorubicine [Inn-French]
- Pidorubicinum [Inn-Latin]
- Ridorubicin
Ellence Brand Names Mixture
- No information avaliable
Ellence Chemical_Formula
C27H29NO11
Ellence RX_link
http://www.rxlist.com/cgi/generic2/epirub.htm
Ellence fda sheet
Ellence msds (material safety sheet)
Ellence Synthesis Reference
Smith et al.; J.Org.Chem.; 42;3653,3658(1977)
Ellence Molecular Weight
543.519 g/mol
Ellence Melting Point
344.53oC
Ellence H2O Solubility
0.093 mg/ml
Ellence State
Solid
Ellence LogP
0.455
Ellence Dosage Forms
Powder for solution; Solution
Ellence Indication
For use as a component of adjuvant therapy in patients with evidence of axillary node tumor involvement following resection of primary breast cancer
Ellence Pharmacology
Epirubicin is an antineoplastic in the anthracycline class. General properties of drugs in this class include: interaction with DNA in a variety of different ways including intercalation (squeezing between the base pairs), DNA strand breakage and inhibition with the enzyme topoisomerase II. Most of these compounds have been isolated from natural sources and antibiotics. However, they lack the specificity of the antimicrobial antibiotics and thus produce significant toxicity. The anthracyclines are among the most important antitumor drugs available. Doxorubicin is widely used for the treatment of several solid tumors while daunorubicin and idarubicin are used exclusively for the treatment of leukemia. Epirubicin may also inhibit polymerase activity, affect regulation of gene expression, and produce free radical damage to DNA. Epirubicin possesses an antitumor effect against a wide spectrum of tumors, either grafted or spontaneous. The anthracyclines are cell cycle-nonspecific.
Ellence Absorption
100%
Ellence side effects and Toxicity
bone marrow aplasia, grade 4 mucositis, and gastrointestinal bleeding
Ellence Patient Information
Patients should be informed of the expected adverse effects of epirubicin, including gastrointestinal symptoms (nausea, vomiting, diarrhea, and stomatitis) and potential neutropenic complications. Patients should consult their physician if vomiting, dehydration, fever, evidence of infection, symptoms of CHF, or injection-site pain occurs following therapy with ELLENCE. Patients should be informed that they will almost certainly develop alopecia. Patients should be advised that their urine may appear red for 1 to 2 days after administration of ELLENCE and that they should not be alarmed. Patients should understand that there is a risk of irreversible myocardial damage associated with treatment with ELLENCE, as well as a risk of treatment-related leukemia. Because epirubicin may induce chromosomal damage in sperm, men undergoing treatment with ELLENCE should use effective contraceptive methods. Women treated with ELLENCE may develop irreversible amenorrhea, or premature menopause.
Ellence Organisms Affected
Humans and other mammals
