EMB
EMB Brand names, EMB Analogs
EMB Brand Names Mixture
- No information avaliable
EMB Chemical_Formula
C5H11Cl2N
EMB RX_link
http://www.rxlist.com/cgi/generic3/mustargen.htm
EMB fda sheet
EMB msds (material safety sheet)
EMB Synthesis Reference
Hansen, T. K., et al.; J.Org.Chem.; 58; 6;1359-1366(1993)
EMB Molecular Weight
156.053 g/mol
EMB Melting Point
108-111 oC
EMB H2O Solubility
1.2E+004 mg/L
EMB State
Solid
EMB LogP
1.412
EMB Dosage Forms
Powdered vials for injection; Skin solution; Ointment
EMB Indication
For the palliative treatment of Hodgkin's disease (Stages III and IV), lymphosarcoma, chronic myelocytic or chronic lymphocytic leukemia, polycythemia vera, mycosis fungoides, and bronchogenic carcinoma. Also for the palliative treatment of metastatic carcinoma resulting in effusion.
EMB Pharmacology
Mechlorethamine also known as mustine, nitrogen mustard, and HN2, is the prototype anticancer chemotherapeutic drug. Successful clinical use of mechlorethamine gave birth to the field of anticancer chemotherapy. The drug is an analogue of mustard gas and was derived from toxic gas warfare research. It belongs to the group of nitrogen mustard alkylating agents. Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death.
EMB Absorption
Partially absorbed following intracavitary administration, most likely due to rapid deactivation by body fluids.
EMB side effects and Toxicity
Symptoms of overexposure include severe leukopenia, anemia, thrombocytopenia, and a hemorrhagic diathesis with subsequent delayed bleeding may develop. Death may follow. The intravenous LD50 is 2 mg/kg and 1.6 mg/kg in mouse and rat, respectively.
EMB Patient Information
PATIENT INFORMATION
NOTE: This information does not apply if mechlorethamine is applied to skin.
Please see "For the patient: Mechlorethamine for skin".
Mechlorethamine (meh-klor-ETH-ah-meen) is a drug that is used to treat some
kinds of cancer. It is a clear liquid that is usually injected into a vein.
A blood sample will be taken before each treatment. The dose and timing of
your chemotherapy may be changed based on your blood counts and/or other side
effects.
Your doctor may tell you to drink lots of liquids (8-12 cups a day). This
helps prevent kidney problems in some kinds of cancer.
Other drugs may interact with mechlorethamine. Tell your doctor if you are
taking any other drugs as your dose may need to be changed. Check with your
doctor or pharmacist before you start taking any new drugs.
The drinking of alcohol (in small amounts) will not affect the safety or
usefulness of mechlorethamine.
Mechlorethamine may cause sterility in men and menopause in women which may
be permanent. If you plan to have children, discuss this with your doctor
before being treated with mechlorethamine.
Mechlorethamine may damage sperm and may harm the baby if used during pregnancy.
It is best to use birth control while being treated with mechlorethamine. Tell
your doctor right away if you or your partner becomes pregnant. Do not breast
feed during treatment.
Tell doctors or dentists that you are being treated with mechlorethamine before
you receive any treatment from them.
SEE YOUR DOCTOR OR GET EMERGENCY HELP IMMEDIATELY IF YOU HAVE:
Signs of an infection such as fever (over 100�F or 38�C); chills; cough; sore
throat; pain or burning when you pass urine; redness, pain or swelling of any
area of your body; sores forming anywhere on your body.
Signs of bleeding problems such as black, tarry stools; blood in urine; pinpoint
red spots on skin.
SEE YOUR DOCTOR AS SOON AS POSSIBLE (DURING OFFICE HOURS) IF YOU HAVE:
Signs of kidney problems such as lower back or side pain, swelling of feet or
lower legs, numbness or tingling in feet or hands.
Signs of gout such as joint pain.
CHECK WITH YOUR DOCTOR IF ANY OF THE FOLLOWING CONTINUE OR BOTHER YOU:
Uncontrolled nausea, vomiting or diarrhea.
Easy bruising or bleeding.
Redness, swelling, pain or sores where the needle was placed.
Redness, swelling, pain or sores on your lips, tongue, mouth or throat.
Skin rash.
NOTE: This information does not apply if mechlorethamine is applied to skin.
Please see "For the patient: Mechlorethamine for skin".
Mechlorethamine (meh-klor-ETH-ah-meen) is a drug that is used to treat some
kinds of cancer. It is a clear liquid that is usually injected into a vein.
A blood sample will be taken before each treatment. The dose and timing of
your chemotherapy may be changed based on your blood counts and/or other
side effects.
Your doctor may tell you to drink lots of liquids (8-12 cups a day). This
helps prevent kidney problems in some kinds of cancer.
Other drugs may interact with mechlorethamine. Tell your doctor if you are
taking any other drugs as your dose may need to be changed. Check with your
doctor or pharmacist before you start taking any new drugs.
The drinking of alcohol (in small amounts) will not affect the safety or
usefulness of mechlorethamine.
Mechlorethamine may cause sterility in men and menopause in women which may
be permanent. If you plan to have children, discuss this with your doctor
before being treated with mechlorethamine.
Mechlorethamine may damage sperm and may harm the baby if used during pregnancy.
It is best to use birth control while being treated with mechlorethamine. Tell
your doctor right away if you or your partner becomes pregnant. Do not breast
feed during treatment.
Tell doctors or dentists that you are being treated with mechlorethamine before
you receive any treatment from them.
SEE YOUR DOCTOR OR GET EMERGENCY HELP IMMEDIATELY IF YOU HAVE:
Signs of an infection such as fever (over 100�F or 38�C); chills; cough; sore
throat; pain or burning when you pass urine; redness, pain or swelling of any
area of your body; sores forming anywhere on your body.
Signs of bleeding problems such as black, tarry stools; blood in urine; pinpoint
red spots on skin.
SEE YOUR DOCTOR AS SOON AS POSSIBLE (DURING OFFICE HOURS) IF YOU HAVE:
Signs of kidney problems such as lower back or side pain, swelling of feet or
lower legs, numbness or tingling in feet or hands.
Signs of gout such as joint pain.
CHECK WITH YOUR DOCTOR IF ANY OF THE FOLLOWING CONTINUE OR BOTHER YOU:
Uncontrolled nausea, vomiting or diarrhea.
Easy bruising or bleeding.
Redness, swelling, pain or sores where the needle was placed.
Redness, swelling, pain or sores on your lips, tongue, mouth or throat.
Skin rash.
NOTE: This information does not apply if mechlorethamine is applied to skin.
Please see "For the patient: Mechlorethamine for skin".
Mechlorethamine (meh-klor-ETH-ah-meen) is a drug that is used to treat some
kinds of cancer. It is a clear liquid that is usually injected into a vein.
A blood sample will be taken before each treatment. The dose and timing of
your chemotherapy may be changed based on your blood counts and/or other side
effects.
Your doctor may tell you to drink lots of liquids (8-12 cups a day). This
helps prevent kidney problems in some kinds of cancer.
Other drugs may interact with mechlorethamine. Tell your doctor if you are
taking any other drugs as your dose may need to be changed. Check with your
doctor or pharmacist before you start taking any new drugs.
The drinking of alcohol (in small amounts) will not affect the safety or
usefulness of mechlorethamine.
Mechlorethamine may cause sterility in men and menopause in women which may
be permanent. If you plan to have children, discuss this with your doctor
before being treated with mechlorethamine.
Mechlorethamine may damage sperm and may harm the baby if used during pregnancy.
It is best to use birth control while being treated with mechlorethamine. Tell
your doctor right away if you or your partner becomes pregnant. Do not breast
feed during treatment.
Tell doctors or dentists that you are being treated with mechlorethamine before
you receive any treatment from them.
SEE YOUR DOCTOR OR GET EMERGENCY HELP IMMEDIATELY IF YOU HAVE:
Signs of an infection such as fever (over 100�F or 38�C); chills; cough; sore
throat; pain or burning when you pass urine; redness, pain or swelling of any
area of your body; sores forming anywhere on your body.
Signs of bleeding problems such as black, tarry stools; blood in urine; pinpoint
red spots on skin.
SEE YOUR DOCTOR AS SOON AS POSSIBLE (DURING OFFICE HOURS) IF YOU HAVE:
Signs of kidney problems such as lower back or side pain, swelling of feet or
lower legs, numbness or tingling in feet or hands.
Signs of gout such as joint pain.
CHECK WITH YOUR DOCTOR IF ANY OF THE FOLLOWING CONTINUE OR BOTHER YOU:
Uncontrolled nausea, vomiting or diarrhea.
Easy bruising or bleeding.
Redness, swelling, pain or sores where the needle was placed.
Redness, swelling, pain or sores on your lips, tongue, mouth or throat.
Skin rash.
NOTE: This information does not apply if mechlorethamine is applied to skin.
Please see "For the patient: Mechlorethamine for skin".
Mechlorethamine (meh-klor-ETH-ah-meen) is a drug that is used to treat some
kinds of cancer. It is a clear liquid that is usually injected into a vein.
A blood sample will be taken before each treatment. The dose and timing of
your chemotherapy may be changed based on your blood counts and/or other
side effects.
Your doctor may tell you to drink lots of liquids (8-12 cups a day). This
helps prevent kidney problems in some kinds of cancer.
Other drugs may interact with mechlorethamine. Tell your doctor if you are
taking any other drugs as your dose may need to be changed. Check with your
doctor or pharmacist before you start taking any new drugs.
The drinking of alcohol (in small amounts) will not affect the safety or
usefulness of mechlorethamine.
Mechlorethamine may cause sterility in men and menopause in women which may
be permanent. If you plan to have children, discuss this with your doctor
before being treated with mechlorethamine.
Mechlorethamine may damage sperm and may harm the baby if used during pregnancy.
It is best to use birth control while being treated with mechlorethamine. Tell
your doctor right away if you or your partner becomes pregnant. Do not breast
feed during treatment.
Tell doctors or dentists that you are being treated with mechlorethamine before
you receive any treatment from them.
SEE YOUR DOCTOR OR GET EMERGENCY HELP IMMEDIATELY IF YOU HAVE:
Signs of an infection such as fever (over 100�F or 38�C); chills; cough; sore
throat; pain or burning when you pass urine; redness, pain or swelling of any
area of your body; sores forming anywhere on your body.
Signs of bleeding problems such as black, tarry stools; blood in urine; pinpoint
red spots on skin.
SEE YOUR DOCTOR AS SOON AS POSSIBLE (DURING OFFICE HOURS) IF YOU HAVE:
Signs of kidney problems such as lower back or side pain, swelling of feet or
lower legs, numbness or tingling in feet or hands.
Signs of gout such as joint pain.
CHECK WITH YOUR DOCTOR IF ANY OF THE FOLLOWING CONTINUE OR BOTHER YOU:
Uncontrolled nausea, vomiting or diarrhea.
Easy bruising or bleeding.
Redness, swelling, pain or sores where the needle was placed.
Redness, swelling, pain or sores on your lips, tongue, mouth or throat.
Skin rash.
EMB Organisms Affected
Humans and other mammals
