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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C41H64O14
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RX_link
http://www.rxlist.com/cgi/generic/dig.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
S. Smith, J. Chem. Soc. 1930, 508
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Molecular Weight
780.938 g/mol
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Melting Point
248-250 oC
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H2O Solubility
Insoluble
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State
Solid
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LogP
1.969
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Dosage Forms
Tablet; Capsule; Injection
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Indication
For the treatment and management of congestive cardiac insufficiency, arrhythmias and heart failure.
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Pharmacology
Digoxin, a cardiac glycoside similar to digitoxin, is used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms, and to control ventricular rate in the treatment of chronic atrial fibrillation.
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Absorption
Absorption of digoxin from the elixir pediatric formulation has been demonstrated to be 70% to 85% complete (90% to 100% from the capsules, and 60% to 80% for tablets).
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side effects and Toxicity
Toxicity includes ventricular tachycardia or ventricular fibrillation, or progressive bradyarrhythmias, or heart block. LD50 = 7.8 mg/kg (orally in mice).
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Patient Information
Digoxin is used for the treatment of congestive heart failure and for irregular heartbeat. Notify your physician
if you are pregnant or nursing. Do not stop taking digoxin without talking with your physician. Digoxin may be taken
with or without food. It should be taken at approximately the same time each morning. Do not take over-the-counter
antacids, cough, cold, allergy or diet medications without notifying your physician and pharmacist. Notify your
physician if you develop an irregular heartbeat, trouble breathing, skin rash, nausea, diarrhea, blurred or yellow
vision, or unusual weakness or tiredness.
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Organisms Affected
Humans and other mammals