Digitalis Glycoside
Brand names,
Digitalis Glycoside
Analogs
Digitalis Glycoside
Brand Names Mixture
Digitalis Glycoside
Chemical_Formula
C41H64O14
Digitalis Glycoside
RX_link
http://www.rxlist.com/cgi/generic/dig.htm
Digitalis Glycoside
fda sheet
Digitalis Glycoside
msds (material safety sheet)
Digitalis Glycoside
Synthesis Reference
S. Smith, J. Chem. Soc. 1930, 508
Digitalis Glycoside
Molecular Weight
780.938 g/mol
Digitalis Glycoside
Melting Point
248-250 oC
Digitalis Glycoside
H2O Solubility
Insoluble
Digitalis Glycoside
State
Solid
Digitalis Glycoside
LogP
1.969
Digitalis Glycoside
Dosage Forms
Tablet; Capsule; Injection
Digitalis Glycoside
Indication
For the treatment and management of congestive cardiac insufficiency, arrhythmias and heart failure.
Digitalis Glycoside
Pharmacology
Digoxin, a cardiac glycoside similar to digitoxin, is used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms, and to control ventricular rate in the treatment of chronic atrial fibrillation.
Digitalis Glycoside
Absorption
Absorption of digoxin from the elixir pediatric formulation has been demonstrated to be 70% to 85% complete (90% to 100% from the capsules, and 60% to 80% for tablets).
Digitalis Glycoside
side effects and Toxicity
Toxicity includes ventricular tachycardia or ventricular fibrillation, or progressive bradyarrhythmias, or heart block. LD50 = 7.8 mg/kg (orally in mice).
Digitalis Glycoside
Patient Information
Digoxin is used for the treatment of congestive heart failure and for irregular heartbeat. Notify your physician
if you are pregnant or nursing. Do not stop taking digoxin without talking with your physician. Digoxin may be taken
with or without food. It should be taken at approximately the same time each morning. Do not take over-the-counter
antacids, cough, cold, allergy or diet medications without notifying your physician and pharmacist. Notify your
physician if you develop an irregular heartbeat, trouble breathing, skin rash, nausea, diarrhea, blurred or yellow
vision, or unusual weakness or tiredness.
Digitalis Glycoside
Organisms Affected
Humans and other mammals