Doxil

• Antibiotics
• Antineoplastic Agents
• ATC:L01DB01

• ADM
• Adriablastin
• Adriamycin
• Adriamycin PFS
• Adriamycin RDF
• Adriamycin Semiquinone
• Adriblastin
• Adriblastina
• Caelyx
• DM2
• Doxil
• Doxo
• Doxorubicin HCl
• Doxorubicin Hydrochloride
• Doxorubicin [Usan:Ban:Inn]
• Doxorubicina [Inn-Spanish]
• Doxorubicine [Inn-French]
• Doxorubicinum [Inn-Latin]
• RDF Rubex
• Rubex

• No information avaliable

C₂₇H₂₉NO₁₁

http://www.rxlist.com/cgi/generic2/doxor.htm

Doxil FDA

Harrison et al.; Biochem. biophys. Acta; 21; 150, 152(1956)

543.519 g/mol

204 - 205^oC

Soluble

Solid

0.455

Powder for solution

For the treatment of Koposi's sarcome connected to AIDS.

Doxorubicin is an antineoplastic in the anthracycline class. General properties of drugs in this class include: interaction with DNA in a variety of different ways including intercalation (squeezing between the base pairs), DNA strand breakage and inhibition with the enzyme topoisomerase II. Most of these compounds have been isolated from natural sources and antibiotics. However, they lack the specificity of the antimicrobial antibiotics and thus produce significant toxicity. The anthracyclines are among the most important antitumor drugs available. Doxorubicin is widely used for the treatment of several solid tumors while daunorubicin and idarubicin are used exclusively for the treatment of leukemia. Doxorubicin may also inhibit polymerase activity, affect regulation of gene expression, and produce free radical damage to DNA. Doxorubicin possesses an antitumor effect against a wide spectrum of tumors, either grafted or spontaneous. The anthracyclines are cell cycle-nonspecific.

No information avaliable

LD₅₀=21800 ug/kg (rat, subcutaneous)

Patients and their caregivers should be informed of the expected adverse effects of DOXIL^® , particularly hand-foot syndrome, stomatitis, and neutropenia and related complications of neutropenic fever, infection, and sepsis.

Hand-Foot Syndrome (HFS): Patients who experience tingling or burning, redness, flaking, bothersome swelling, small blisters, or small sores on the palms of their hands or soles of their feet (symptoms of Hand-Foot Syndrome) should notify their physician.

Stomatitis: Patients who experience painful redness, swelling, or sores in the mouth (symptoms of stomatitis) should notify their physician.

Fever and Neutropenia Patients who develop a fever of 100.5°F or higher should notify their physician.

Nausea, vomiting, tiredness, weakness, rash, or mild hair loss Patients who develop any of these symptoms should notify their physician.

Following its administration, DOXIL^® may impart a reddish orange color to the urine and other body fluids. This nontoxic reaction is due to the color of the product and will dissipate as the drug is eliminated from the body.

Humans and other mammals