PharmacyCodes



Dirithromycin en es it fr

Dirithromycin Brand names, Dirithromycin Analogs

Dirithromycin Brand Names Mixture

  • No information avaliable

Dirithromycin Chemical_Formula

C42H78N2O14

Dirithromycin RX_link

http://www.rxlist.com/cgi/generic2/dirthromycin.htm

Dirithromycin fda sheet

Dirithromycin msds (material safety sheet)

Dirithromycin Synthesis Reference

No information avaliable

Dirithromycin Molecular Weight

835.074 g/mol

Dirithromycin Melting Point

No information avaliable

Dirithromycin H2O Solubility

Poor

Dirithromycin State

Solid

Dirithromycin LogP

2.833

Dirithromycin Dosage Forms

Tablets (enteric coated, 250mg)

Dirithromycin Indication

For the treatment of the following mild-to-moderate infections caused by susceptible strains of microorganisms: acute bacterial exacerbations of chronic bronchitis, secondary bacterial infection of acute bronchitis, community-acquired pneumonia, pharyngitis/tonsilitis, and uncomplicated skin and skin structure infections.

Dirithromycin Pharmacology

Dirithromycin is a pro-drug which is converted non-enzymatically during intestinal absorption into the microbiologically active moiety erythromycylamine. Erythromycylamine exerts its activity by binding to the 50S ribosomal subunits of susceptible mircoorganisms resulting in inhibition of protein synthesis. Dirithromycin/erythromycylamine has been shown to be active against most strains of the following microorganisms both in vitro and in clinical infections: Staphylococcus aureus (methicillin-susceptible strains only), Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae, Legionella pneumophila, Moraxella catarrhalis, and Mycoplasma pneumoniae.

Dirithromycin Absorption

Oral dirithromycin is rapidly absorbed, with an absolute bioavailability of approximately 10%. Dietary fat has little or no effect on the bioavailability of dirithromycin.

Dirithromycin side effects and Toxicity

The toxic symptoms following an overdose of a macrolide antibiotic may include nausea, vomiting, epigastric distress, and diarrhea.

Dirithromycin Patient Information

Dirithromycin Organisms Affected

Enteric bacteria and other eubacteria