Differin
Differin Brand names, Differin Analogs
Differin Brand Names Mixture
- No information avaliable
Differin Chemical_Formula
C28H28O3
Differin RX_link
http://www.rxlist.com/cgi/generic3/adapalene.htm
Differin fda sheet
Differin msds (material safety sheet)
Differin Synthesis Reference
No information avaliable
Differin Molecular Weight
412.52 g/mol
Differin Melting Point
No information avaliable
Differin H2O Solubility
Practically Insoluble
Differin State
Solid
Differin LogP
7.884
Differin Dosage Forms
Gel (0.1%); Solution; Pledglets; Cream
Differin Indication
For the topical treatment of comedo, papular and pustular acne (acne vulgaris) of the face, chest or back.
Differin Pharmacology
Adapalene is a chemically stable retinoid-like compound. Biochemical and pharmacological profile studies have demonstrated that adapalene is a modulator of cellular differentiation, keratinization, and inflammatory processes all of which represent important features in the pathology of acne vulgaris.
Differin Absorption
Absorption of adapalene through human skin is low. Only trace amounts (<0.25 ng/mL) of parent substance have been found in the plasma of acne patients following chronic topical application of adapalene in controlled clinical trials
Differin side effects and Toxicity
The acute oral toxicity of adapalene in mice and rats is greater than 10 mL/kg. Chronic ingestion of the drug may lead to the same side effects as those associated with excessive oral intake of Vitamin A.
Differin Patient Information
Differin Organisms Affected
Humans and other mammals
