Adapalenum [INN-Latin]

Adapalenum [INN-Latin] Brand names, Adapalenum [INN-Latin] Analogs

Adapalenum [INN-Latin] Brand Names Mixture

No information avaliable

Adapalenum [INN-Latin] Chemical_Formula

C₂₈H₂₈O₃

Adapalenum [INN-Latin] RX_link

http://www.rxlist.com/cgi/generic3/adapalene.htm

Adapalenum [INN-Latin] fda sheet

Adapalenum_[INN-Latin] FDA

Adapalenum [INN-Latin] msds (material safety sheet)

Adapalenum_[INN-Latin] MSDS

Adapalenum [INN-Latin] Synthesis Reference

No information avaliable

Adapalenum [INN-Latin] Molecular Weight

412.52 g/mol

Adapalenum [INN-Latin] Melting Point

No information avaliable

Adapalenum [INN-Latin] H₂O Solubility

Practically Insoluble

Adapalenum [INN-Latin] State

Solid

Adapalenum [INN-Latin] LogP

7.884

Adapalenum [INN-Latin] Dosage Forms

Gel (0.1%); Solution; Pledglets; Cream

Adapalenum [INN-Latin] Indication

For the topical treatment of comedo, papular and pustular acne (acne vulgaris) of the face, chest or back.

Adapalenum [INN-Latin] Pharmacology

Adapalene is a chemically stable retinoid-like compound. Biochemical and pharmacological profile studies have demonstrated that adapalene is a modulator of cellular differentiation, keratinization, and inflammatory processes all of which represent important features in the pathology of acne vulgaris.

Adapalenum [INN-Latin] Absorption

Absorption of adapalene through human skin is low. Only trace amounts (<0.25 ng/mL) of parent substance have been found in the plasma of acne patients following chronic topical application of adapalene in controlled clinical trials

Adapalenum [INN-Latin] side effects and Toxicity

The acute oral toxicity of adapalene in mice and rats is greater than 10 mL/kg. Chronic ingestion of the drug may lead to the same side effects as those associated with excessive oral intake of Vitamin A.

Adapalenum [INN-Latin] Patient Information

Adapalenum [INN-Latin] Organisms Affected

Humans and other mammals