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Brand names,
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Analogs
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Brand Names Mixture
- Caldomine DH Adulte (Hydrocodone Bitartrate + Pheniramine Maleate + Phenylpropanolamine Hydrochloride + Pyrilamine Maleate)
- Caldomine DH Enfant (Hydrocodone Bitartrate + Pheniramine Maleate + Phenylpropanolamine Hydrochloride + Pyrilamine Maleate)
- Coristine-DH Liq (Hydrocodone Bitartrate + Phenylephrine Hydrochloride)
- Dalmacol (Alcohol Anhydrous + Doxylamine Succinate + Etafedrin Hydrochloride + Hydrocodone Bitartrate + Sodium Citrate)
- Dimetane Expectorant-DC Syr (Brompheniramine Maleate + Guaifenesin + Hydrocodone Bitartrate + Phenylephrine Hydrochloride + Phenylpropanolamine Hydrochloride)
- Dimetane Expectorant-DC Syrup (Brompheniramine Maleate + Guaifenesin + Hydrocodone Bitartrate + Phenylephrine Hydrochloride)
- Hycomine-S (Ammonium Chloride + Hydrocodone Bitartrate + Phenylephrine Hydrochloride + Pyrilamine Maleate)
- Mercodol with Decapryn (Doxylamine Succinate + Etafedrin Hydrochloride + Hydrocodone Bitartrate + Sodium Citrate)
- Novahistex Dh Expectorant (Guaifenesin + Hydrocodone Bitartrate + Phenylephrine Hydrochloride)
- Novahistex Dh Syrup (Hydrocodone Bitartrate + Phenylephrine Hydrochloride)
- Ratio-Calmydone (Doxylamine Succinate + Etafedrin Hydrochloride + Hydrocodone Bitartrate + Sodium Citrate)
- Ratio-Coristex-DH (Hydrocodone Bitartrate + Phenylephrine Hydrochloride)
- Solucodan Syrup (Hydrocodone Bitartrate + Menthol + Potassium Guaiacol Sulphonate + Sodium Citrate)
- Solucodan-H (Diphenylpyraline Hydrochloride + Hydrocodone Bitartrate + Menthol + Potassium Guaiacol Sulphonate + Sodium Citrate)
- Triaminic Expectorant DH Syrup (Guaifenesin + Hydrocodone Bitartrate + Pheniramine Maleate + Phenylpropanolamine Hydrochloride + Pyrilamine Maleate)
- Tussaminic DH Forte Syrup (Hydrocodone Bitartrate + Pheniramine Maleate + Phenylpropanolamine Hydrochloride + Pyrilamine Maleate)
- Tussaminic DH Pediatric Syrup (Hydrocodone Bitartrate + Pheniramine Maleate + Phenylpropanolamine Hydrochloride + Pyrilamine Maleate)
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Chemical_Formula
C18H21NO3
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RX_link
http://www.rxlist.com/cgi/generic/hydrocod.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
K. Pfister, M. Tishler; U.S. Pat. 2,715,626 (1955)
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Molecular Weight
299.364 g/mol
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Melting Point
198oC
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H2O Solubility
Insoluble
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State
Solid
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LogP
2.041
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Dosage Forms
Tablets; Syrup; Liquid mixtures with other analgesics
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Indication
For relief of moderate to moderately severe pain.
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Pharmacology
Hydrocodone, a semisynthetic opiate agonist and hydrogenated ketone derivative, is similar to other phenanthrene derivatives, such as codeine. Used as an analgesic, hydrocodone is combined with acetaminophen, ibuprofen, or aspirin to treat pain. Used as an antitussive, hydrocodone is combined with phenylephrine, pseudoephedrine, phenylpropanolamine, guaifenesin, pyrilamine, pheniramine, or chlorpheniramine.
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Absorption
Well absorbed from the gastrointestinal tract.
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side effects and Toxicity
Symptoms of overdose include respiratory depression (a decrease in respiratory rate and/or tidal volume, Cheyne-Stokes respiration, cyanosis), extreme somnolence progressing to stupor or coma, skeletal muscle flaccidity, dizziness, ringing in the ears, confusion, blurred vision, eye problems, cold and clammy skin, and sometimes bradycardia and hypotension. In severe overdose, apnea, circulatory collapse, cardiac arrest and death may occur. LD50=85.7mg/kg (subcutaneous, in mice).
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Patient Information
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Organisms Affected
Humans and other mammals