Demeclocycline hydrochloride en es it fr

Demeclocycline hydrochloride Brand names, Demeclocycline hydrochloride Analogs

Demeclocycline hydrochloride Brand Names Mixture

  • No information avaliable

Demeclocycline hydrochloride Chemical_Formula


Demeclocycline hydrochloride RX_link

Demeclocycline hydrochloride fda sheet

Demeclocycline hydrochloride msds (material safety sheet)

Demeclocycline_hydrochloride MSDS

Demeclocycline hydrochloride Synthesis Reference

No information avaliable

Demeclocycline hydrochloride Molecular Weight

464.853 g/mol

Demeclocycline hydrochloride Melting Point

220-223 oC

Demeclocycline hydrochloride H2O Solubility

1520 mg/L

Demeclocycline hydrochloride State


Demeclocycline hydrochloride LogP


Demeclocycline hydrochloride Dosage Forms

Tablet (150 mg/300 mg)

Demeclocycline hydrochloride Indication

Used primarily to treat Lyme disease, acne, and bronchitis. Also indicated (but rarely used) to treat urinary tract infections, gum disease, malaria, and other bacterial infections such as gonorrhea and chlamydia. One of its other registered uses is the treatment of hyponatremia (low blood sodium concentration) due to the syndrome of inappropriate antidiuretic hormone (SIADH) where fluid restriction alone has been ineffective.

Demeclocycline hydrochloride Pharmacology

Demeclocycline is a tetracycline antibiotic active against the following microorganisms: Rickettsiae (Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsial pox, tick fevers), Mycoplasma pneumoniae (PPLO, Eaton agent), agents of psittacosis and ornithosis, agents of lymphogranulomavenereum and granuloma inguinale, the spirochetal agent of relapsing fever (Borrelia recurrentis), Haemophilus ducreyi (chancroid), Yersinia pestis, Pasteurella pestis and Pasteurella tularensis, Bartonella bacilliformis, Bacteroides species, Vibrio comma and Vibrio fetus, and Brucella species (in conjunction with streptomycin). Demeclocycline inhibits cell growth by inhibiting translation. Demeclocycline is lipophilic and can easily pass through the cell membrane or passively diffuses through porin channels in the bacterial membrane. Demeclocycline is bacteriostatic (it impairs bacterial growth but does not kill bacteria directly). Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.

Demeclocycline hydrochloride Absorption

Tetracyclines are readily absorbed.

Demeclocycline hydrochloride side effects and Toxicity

Oral, rat: LD50 = 2372 mg/kg

Demeclocycline hydrochloride Patient Information

Demeclocycline hydrochloride is a pill given by mouth, usually 2 to 4 times a day. Take the pill on an empty stomach with a full glass of water, 1 hour before or 2 hours after eating a meal or dairy products like milk, yogurt, and ice cream. If you have nausea when taking the medicine, take it with a cracker but no dairy products. If you are also taking iron pills, take the iron pills 2 hours before or 3 hours after the demeclocycline hydrochloride pill. Keep the medicine in a tightly closed container away from heat and moisture and out of the reach of children and pets. Do not drive a car or operate heavy machinery until you know the effect that demeclocycline hydrochloride has on you. If you are dizzy, lightheaded, or feel tired, you should not drive or operate heavy machinery. Stop the drug and call your doctor or nurse right away if you develop a rash, fever, muscle aches, diarrhea with abdominal cramping, or blood or pus in your stool. This can be a serious reaction and needs to be treated right away.

Demeclocycline hydrochloride Organisms Affected

Enteric bacteria and other eubacteria