6-Demethyl-7-chlorotetracycline en es it fr

6-Demethyl-7-chlorotetracycline Brand names, 6-Demethyl-7-chlorotetracycline Analogs

6-Demethyl-7-chlorotetracycline Brand Names Mixture

  • No information avaliable

6-Demethyl-7-chlorotetracycline Chemical_Formula


6-Demethyl-7-chlorotetracycline RX_link


6-Demethyl-7-chlorotetracycline fda sheet

6-Demethyl-7-chlorotetracycline msds (material safety sheet)

6-Demethyl-7-chlorotetracycline MSDS

6-Demethyl-7-chlorotetracycline Synthesis Reference

No information avaliable

6-Demethyl-7-chlorotetracycline Molecular Weight

464.853 g/mol

6-Demethyl-7-chlorotetracycline Melting Point

220-223 oC

6-Demethyl-7-chlorotetracycline H2O Solubility

1520 mg/L

6-Demethyl-7-chlorotetracycline State


6-Demethyl-7-chlorotetracycline LogP


6-Demethyl-7-chlorotetracycline Dosage Forms

Tablet (150 mg/300 mg)

6-Demethyl-7-chlorotetracycline Indication

Used primarily to treat Lyme disease, acne, and bronchitis. Also indicated (but rarely used) to treat urinary tract infections, gum disease, malaria, and other bacterial infections such as gonorrhea and chlamydia. One of its other registered uses is the treatment of hyponatremia (low blood sodium concentration) due to the syndrome of inappropriate antidiuretic hormone (SIADH) where fluid restriction alone has been ineffective.

6-Demethyl-7-chlorotetracycline Pharmacology

Demeclocycline is a tetracycline antibiotic active against the following microorganisms: Rickettsiae (Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsial pox, tick fevers), Mycoplasma pneumoniae (PPLO, Eaton agent), agents of psittacosis and ornithosis, agents of lymphogranulomavenereum and granuloma inguinale, the spirochetal agent of relapsing fever (Borrelia recurrentis), Haemophilus ducreyi (chancroid), Yersinia pestis, Pasteurella pestis and Pasteurella tularensis, Bartonella bacilliformis, Bacteroides species, Vibrio comma and Vibrio fetus, and Brucella species (in conjunction with streptomycin). Demeclocycline inhibits cell growth by inhibiting translation. Demeclocycline is lipophilic and can easily pass through the cell membrane or passively diffuses through porin channels in the bacterial membrane. Demeclocycline is bacteriostatic (it impairs bacterial growth but does not kill bacteria directly). Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.

6-Demethyl-7-chlorotetracycline Absorption

Tetracyclines are readily absorbed.

6-Demethyl-7-chlorotetracycline side effects and Toxicity

Oral, rat: LD50 = 2372 mg/kg

6-Demethyl-7-chlorotetracycline Patient Information

Demeclocycline hydrochloride is a pill given by mouth, usually 2 to 4 times a day. Take the pill on an empty stomach with a full glass of water, 1 hour before or 2 hours after eating a meal or dairy products like milk, yogurt, and ice cream. If you have nausea when taking the medicine, take it with a cracker but no dairy products. If you are also taking iron pills, take the iron pills 2 hours before or 3 hours after the demeclocycline hydrochloride pill. Keep the medicine in a tightly closed container away from heat and moisture and out of the reach of children and pets. Do not drive a car or operate heavy machinery until you know the effect that demeclocycline hydrochloride has on you. If you are dizzy, lightheaded, or feel tired, you should not drive or operate heavy machinery. Stop the drug and call your doctor or nurse right away if you develop a rash, fever, muscle aches, diarrhea with abdominal cramping, or blood or pus in your stool. This can be a serious reaction and needs to be treated right away.

6-Demethyl-7-chlorotetracycline Organisms Affected

Enteric bacteria and other eubacteria