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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C18H19N3O5S
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RX_link
http://www.rxlist.com/cgi/generic/cefprozi.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
H. Hoshi et al., U.S. Pat. 4,520,022 (1985)
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Molecular Weight
389.427 g/mol
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Melting Point
218-225oC
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H2O Solubility
55 mg/L
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State
Solid
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LogP
0.209
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Dosage Forms
Cefzil tablets contain cefprozil equivalent to 250 mg or 500 mg of anhydrous cefprozil.
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Indication
For the treatment of the following infections (respiratory, skin, soft tissue, UTI, ENT) caused by; S. pneumoniae, H. influenzae, staphylococci, S. pyogenes (group A beta-hemolytic streptococci), E. coli, P. mirabilis, Klebsiella sp, coagulase-negative staph
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Pharmacology
Cefprozil, a semisynthetic, second-generation cephalosporin, is used to treat otitis media, soft-tissue infections, and respiratory tract infections.
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Absorption
Oral~95%
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side effects and Toxicity
Single 5000 mg/kg oral doses of cefprozil caused no mortality or signs of toxicity in adult, weaning or neonatal rats, or adult mice. A single oral dose of 3000 mg/kg caused diarrhea and loss of appetite in cynomolgus monkeys, but no mortality.
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Patient Information
Cefprozil is an antibiotic use to treat infections such as tonsillitis, ear infections, bronchitis, pneumonia or skin infections. This drug should not be used by those with allergies to the cephalosporin antibiotics. You should also consult with your pharmacist or physician if you are allergic to penicillin before taking this medication. This medication contains phenylalanine; caution is warranted for phenylketonuric patients. This medication has been known to falsely wshow glucose (sugar) in the urine. The most common side effects include nausea, vomiting and diarrhea. This medication should be taken for the full period prescribed. Even if you feel better after a day or two of medication, the full prescription should be taken to fully cure the infection.
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Organisms Affected
Enteric bacteria and other eubacteria