Clofarabine
Clofarabine Brand names, Clofarabine Analogs
Clofarabine Brand Names Mixture
- No information avaliable
Clofarabine Chemical_Formula
C10H11ClFN5O3
Clofarabine RX_link
http://www.rxlist.com/cgi/generic3/clofarabine.htm
Clofarabine fda sheet
Clofarabine msds (material safety sheet)
Clofarabine Synthesis Reference
No information avaliable
Clofarabine Molecular Weight
303.677 g/mol
Clofarabine Melting Point
No information avaliable
Clofarabine H2O Solubility
No information avaliable
Clofarabine State
Solid
Clofarabine LogP
-0.151
Clofarabine Dosage Forms
Solution for intravenous infusion (1 mg/mL, supplied in a 20 mL, single-use vial)
Clofarabine Indication
For the treatment of pediatric patients 1 to 21 years old with relapsed or refractory acute lymphoblastic leukemia after at least two prior regimens.
Clofarabine Pharmacology
Clofarabine is a purine nucleoside antimetabolite. Clofarabine seems to interfere with the growth of cancer cells, which are eventually destroyed. Since the growth of normal body cells also may be affected by clofarabine, other effects also occur. Clofarabine prevents cells from making DNA and RNA by interfering with the synthesis of nucleic acids, thus stopping the growth of cancer cells.
Clofarabine Absorption
No information avaliable
Clofarabine side effects and Toxicity
There were no known overdoses of clofarabine. The highest daily dose administered to a human to date (on a mg/m2 basis) has been 70 mg/m2/day × 5 days (2 pediatric ALL patients). The toxicities included in these 2 patients included grade 4 hyperbilirubinemia, grade 2 and 3 vomiting, and grade 3 maculopapular rash.
Clofarabine Patient Information
Clofarabine Organisms Affected
Humans and other mammals
