Clolar
Clolar Brand names, Clolar Analogs
Clolar Brand Names Mixture
- No information avaliable
Clolar Chemical_Formula
C10H11ClFN5O3
Clolar RX_link
http://www.rxlist.com/cgi/generic3/clofarabine.htm
Clolar fda sheet
Clolar msds (material safety sheet)
Clolar Synthesis Reference
No information avaliable
Clolar Molecular Weight
303.677 g/mol
Clolar Melting Point
No information avaliable
Clolar H2O Solubility
No information avaliable
Clolar State
Solid
Clolar LogP
-0.151
Clolar Dosage Forms
Solution for intravenous infusion (1 mg/mL, supplied in a 20 mL, single-use vial)
Clolar Indication
For the treatment of pediatric patients 1 to 21 years old with relapsed or refractory acute lymphoblastic leukemia after at least two prior regimens.
Clolar Pharmacology
Clofarabine is a purine nucleoside antimetabolite. Clofarabine seems to interfere with the growth of cancer cells, which are eventually destroyed. Since the growth of normal body cells also may be affected by clofarabine, other effects also occur. Clofarabine prevents cells from making DNA and RNA by interfering with the synthesis of nucleic acids, thus stopping the growth of cancer cells.
Clolar Absorption
No information avaliable
Clolar side effects and Toxicity
There were no known overdoses of clofarabine. The highest daily dose administered to a human to date (on a mg/m2 basis) has been 70 mg/m2/day × 5 days (2 pediatric ALL patients). The toxicities included in these 2 patients included grade 4 hyperbilirubinemia, grade 2 and 3 vomiting, and grade 3 maculopapular rash.
Clolar Patient Information
Clolar Organisms Affected
Humans and other mammals
