Clarithromycin

Clarithromycin Brand names, Clarithromycin Analogs

Clarithromycin Brand Names Mixture

No information avaliable

Clarithromycin Chemical_Formula

C₃₈H₆₉NO₁₃

Clarithromycin RX_link

http://www.rxlist.com/cgi/generic/clarith.htm

Clarithromycin fda sheet

Clarithromycin FDA

Clarithromycin msds (material safety sheet)

Clarithromycin Synthesis Reference

Y. Watanabe et al.; U.S. Pat. 4,331803 (1982)

Clarithromycin Molecular Weight

747.953 g/mol

Clarithromycin Melting Point

217 - 220 ^oC

Clarithromycin H₂O Solubility

0.33 mg/L

Clarithromycin State

Solid

Clarithromycin LogP

2.69

Clarithromycin Dosage Forms

Suspension (oral); Tablet; Granules (for oral suspension)

Clarithromycin Indication

For the treatment of bacterial infection of (pharyngitis/tonsillitis, sinusitis, bronchitis, pneumonia, uncomplicated skin and skin structure infections) caused by H. influenzae, M. catarrhalis, M. pneumoniae, S. pneumoniae, C. pneumoniae (TWAR), S. aureus, S. pyogenes, Mycobacterium avium and Mycobacterium intracellulare

Clarithromycin Pharmacology

Clarithromycin, a macrolide antibiotic similar to erythromycin and azithromycin, is effective against Mycobacterium avium complex (MAC) and is used for the treatment of Helicobacter pylori-associated peptic ulcer disease, community-acquired pneumonia, sinusitis, and chronic bronchitis. Clarithromycin is also used to treat respiratory tract, sexually transmitted, otitis media, and AIDS-related infections.

Clarithromycin Absorption

50%

Clarithromycin side effects and Toxicity

Symptoms of toxicity include diarrhea, nausea, abnormal taste, dyspepsia, and abdominal discomfort. Pseudomembraneous colitis has been reported with clarithromycin use, allergic reactions ranging from urticaria and mild skin eruptions to rare cases of anaphylaxis and Stevens-Johnson syndrome have occurred. Rare cases of severe hepatic dysfunctions also have been reported. Hepatic failure is usually reversible, but fatalities have been reported.

Clarithromycin Patient Information

Clarithromycin is an antibiotic used to treat infections such as sinus infections, throat infections, tonsil infections and other lung related infections. It can be used by some patients to prevent infections. It is important that you take this medication for the full period of time your doctor has prescribed it, even if you feel better after a day or two. This medication should not be taken by those with an allergy to erythromycin. There are several significant drug interactions with clarithromycin. Make sure to have your doctor or pharmacist fully evaluate all medications you might be taking and ask them about drug interactions. The most common side effects reported include taste disturbances, diarrhea and nausea, occurring in approximately 3% of patients. Clarithromycin can be taken with or without food. Unlike other suspensions (liquid forms), this suspension should not be refrigerated.

Clarithromycin Organisms Affected

Enteric bacteria and other eubacteria