Cinacalcet
Cinacalcet Brand names, Cinacalcet Analogs
Cinacalcet Brand Names Mixture
- No information avaliable
Cinacalcet Chemical_Formula
C22H22F3N
Cinacalcet RX_link
http://www.rxlist.com/cgi/generic3/sensipar.htm
Cinacalcet fda sheet
Cinacalcet msds (material safety sheet)
Cinacalcet Synthesis Reference
No information avaliable
Cinacalcet Molecular Weight
357.412 g/mol
Cinacalcet Melting Point
No information avaliable
Cinacalcet H2O Solubility
Slightly soluble (in HCl salt form)
Cinacalcet State
Solid
Cinacalcet LogP
6.791
Cinacalcet Dosage Forms
Tablets (light-green, film-coated, oval-shaped tablets for oral administration in strengths of 30 mg, 60 mg, and 90 mg)
Cinacalcet Indication
For the treatment of secondary hyperparathyroidism in patients with Chronic Kidney Disease on dialysis. Also for the treatment of hypercalcemia in patients with parathyroid carcinoma.
Cinacalcet Pharmacology
Cinacalcet is a drug that acts as a calcimimetic (i.e. it mimics the action of calcium on tissues). Secondary hyperparathyroidism (HPT) in patients with chronic kidney disease (CKD) is a progressive disease, associated with increases in parathyroid hormone (PTH) levels and derangements in calcium and phosphorus metabolism. Increased PTH stimulates osteoclastic activity resulting in cortical bone resorption and marrow fibrosis. The goals of treatment of secondary hyperparathyroidism are to lower levels of PTH, calcium, and phosphorus in the blood, in order to prevent progressive bone disease and the systemic consequences of disordered mineral metabolism. In CKD patients on dialysis with uncontrolled secondary HPT, reductions in PTH are associated with a favorable impact on bone-specific alkaline phosphatase (BALP), bone turnover and bone fibrosis. Cinacalcet reduces calcium levels by increasing the sensitivity of the calcium sensing receptor to extracellular calcium.
Cinacalcet Absorption
Rapidly absorbed following oral administration.
Cinacalcet side effects and Toxicity
Doses titrated up to 300 mg once daily have been safely administered to patients on dialysis. Overdosage of cinacalcet may lead to hypocalcemia.
Cinacalcet Patient Information
No information avaliable
Cinacalcet Organisms Affected
Humans and other mammals
