Cerulenin From Cephalosporium Caerulens
Brand names,
Cerulenin From Cephalosporium Caerulens
Analogs
Cerulenin From Cephalosporium Caerulens
Brand Names Mixture
Cerulenin From Cephalosporium Caerulens
Chemical_Formula
C12H17NO3
Cerulenin From Cephalosporium Caerulens
RX_link
No information avaliable
Cerulenin From Cephalosporium Caerulens
fda sheet
Cerulenin From Cephalosporium Caerulens
msds (material safety sheet)
Cerulenin From Cephalosporium Caerulens
Synthesis Reference
No information avaliable
Cerulenin From Cephalosporium Caerulens
Molecular Weight
223.268 g/mol
Cerulenin From Cephalosporium Caerulens
Melting Point
93.5 oC
Cerulenin From Cephalosporium Caerulens
H2O Solubility
Slightly soluble
Cerulenin From Cephalosporium Caerulens
State
Solid
Cerulenin From Cephalosporium Caerulens
LogP
-0.147
Cerulenin From Cephalosporium Caerulens
Dosage Forms
No information avaliable
Cerulenin From Cephalosporium Caerulens
Indication
For use as a biochemical tool, Cerulenin is shown to cause dramatic weight loss in animals
Cerulenin From Cephalosporium Caerulens
Pharmacology
Cerulenin is an antifungal antibiotic isolated from Cephalosporium caerulens. It interrupts fungal growth by inhibiting the biosynthesis of sterols and fatty acids (inhibits bacterial fatty acid synthesis). It also inhibits HMG-CoA synthetase activity. Cerulenin produces metabolic effects similar to effects of leptin, but through mechanisms that are independent of, or down-stream from, both leptin and melanocortin receptors.
Cerulenin From Cephalosporium Caerulens
Absorption
No information avaliable
Cerulenin From Cephalosporium Caerulens
side effects and Toxicity
Oral, mouse LD50: 547 mg/kg. Symptoms of overexposure include moderate to severe erythema (redness) and moderate edema (raised skin), nausea, vomiting, and headache.
Cerulenin From Cephalosporium Caerulens
Patient Information
No information avaliable
Cerulenin From Cephalosporium Caerulens
Organisms Affected
Humans, other mammals, fungi and bacteria