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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C52H88N10O15
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RX_link
http://www.rxlist.com/cgi/generic/caspofungin.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
1093.31 g/mol
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Melting Point
No information avaliable
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H2O Solubility
No information avaliable
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State
Solid
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LogP
-2.798
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Dosage Forms
Powder for solution
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Indication
For the treatment of esophageal candidiasis and invasive aspergillosis in patients who are refractory to or intolerant of other therapies.
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Pharmacology
Caspofungin is an antifungal drug, and belongs to a new class termed the echinocandins. It is used to treat Aspergillus and Candida infection, and works by inhibiting cell wall synthesis. Antifungals in the echinocandin class inhibit the synthesis of glucan in the cell wall, probably via the enzyme 1,3-beta glucan synthase. There is a potential for resistance development to occur, however in vitro resistance development to Caspofungin by Aspergillus species has not been studied.
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Absorption
92% tissue distribution within 36-48 hours after intravenous infusion
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side effects and Toxicity
Side effects include rash, swelling, and nausea (rare)
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Patient Information
No information avaliable
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Organisms Affected
Aspergillis, Candida and other fungi