Bicalutamide
Bicalutamide Brand names, Bicalutamide Analogs
Bicalutamide Brand Names Mixture
- No information avaliable
Bicalutamide Chemical_Formula
C18H14F4N2O4S
Bicalutamide RX_link
http://www.rxlist.com/cgi/generic3/bicalutamide.htm
Bicalutamide fda sheet
Bicalutamide msds (material safety sheet)
Bicalutamide Synthesis Reference
No information avaliable
Bicalutamide Molecular Weight
430.374 g/mol
Bicalutamide Melting Point
191-193 oC
Bicalutamide H2O Solubility
5 mg/L
Bicalutamide State
Solid
Bicalutamide LogP
3.049
Bicalutamide Dosage Forms
Tablet
Bicalutamide Indication
For treatment (together with surgery or LHRH analogue) of advanced prostatic cancer.
Bicalutamide Pharmacology
Bicalutamide is an antineoplastic hormonal agent primarily used in the treatment of prostate cancer. Bicalutamide is a pure, nonsteroidal anti-androgen with affinity for androgen receptors (but not for progestogen, estrogen, or glucocorticoid receptors). Consequently, Bicalutamide blocks the action of androgens of adrenal and testicular origin which stimulate the growth of normal and malignant prostatic tissue. Prostate cancer is mostly androgen-dependent and can be treated with surgical or chemical castration. To date, antiandrogen monotherapy has not consistently been shown to be equivalent to castration.
Bicalutamide Absorption
Bicalutamide is well-absorbed following oral administration, although the absolute bioavailability is unknown.
Bicalutamide side effects and Toxicity
No information avaliable
Bicalutamide Patient Information
Patients should be informed that therapy with CASODEX and the LHRH analogue should be initiated concomitantly, and that they should not interrupt or stop taking these medications without consulting their physician. Treatment with CASODEX should be started at the same time as treatment with an LHRH analogue.
Bicalutamide Organisms Affected
Humans and other mammals
