Casodex
Casodex Brand names, Casodex Analogs
Casodex Brand Names Mixture
- No information avaliable
Casodex Chemical_Formula
C18H14F4N2O4S
Casodex RX_link
http://www.rxlist.com/cgi/generic3/bicalutamide.htm
Casodex fda sheet
Casodex msds (material safety sheet)
Casodex Synthesis Reference
No information avaliable
Casodex Molecular Weight
430.374 g/mol
Casodex Melting Point
191-193 oC
Casodex H2O Solubility
5 mg/L
Casodex State
Solid
Casodex LogP
3.049
Casodex Dosage Forms
Tablet
Casodex Indication
For treatment (together with surgery or LHRH analogue) of advanced prostatic cancer.
Casodex Pharmacology
Bicalutamide is an antineoplastic hormonal agent primarily used in the treatment of prostate cancer. Bicalutamide is a pure, nonsteroidal anti-androgen with affinity for androgen receptors (but not for progestogen, estrogen, or glucocorticoid receptors). Consequently, Bicalutamide blocks the action of androgens of adrenal and testicular origin which stimulate the growth of normal and malignant prostatic tissue. Prostate cancer is mostly androgen-dependent and can be treated with surgical or chemical castration. To date, antiandrogen monotherapy has not consistently been shown to be equivalent to castration.
Casodex Absorption
Bicalutamide is well-absorbed following oral administration, although the absolute bioavailability is unknown.
Casodex side effects and Toxicity
No information avaliable
Casodex Patient Information
Patients should be informed that therapy with CASODEX and the LHRH analogue should be initiated concomitantly, and that they should not interrupt or stop taking these medications without consulting their physician. Treatment with CASODEX should be started at the same time as treatment with an LHRH analogue.
Casodex Organisms Affected
Humans and other mammals
