Arabinosylcytosine
Arabinosylcytosine Brand names, Arabinosylcytosine Analogs
- AR3
- Alexan
- Ara-C
- AraC
- Arabinocytidine
- Arabinofuranosylcytosine
- Arabinosylcytosine
- Arabitin
- Aracytidine
- Aracytin
- Aracytine
- Arafcyt
- Beta-cytosine arabinoside
- Citarabina [INN-Spanish]
- Cytarabin
- Cytarabina
- Cytarabine (JP14/USP)
- Cytarabine [USAN:BAN:INN:JAN]
- Cytarabine(USAN)
- Cytarabinoside
- Cytarabinum [INN-Latin]
- Cytarbel
- Cytosar
- Cytosar-U
- Cytosine 1-beta-D-arabinofuranoside
- Cytosine arabinofuranoside
- Cytosine arabinose
- Cytosine arabinoside
- Cytosine arabinoside (VAN)
- Cytosine beta-D-arabinoside
- Cytosine, 1-beta-D-arabinosyl-
- Cytosine, beta-D-arabinoside
- Cytosine-1-beta-D-arabinofuranoside
- Cytosine-beta-D-arabinofuranoside
- Cytosine-beta-arabinoside
- Depocyt
- Depocyt (TN)
- Depocyt (liposomal)
- Erpalfa
- Iretin
- Spongocytidine
- Tarabine
- Udicil
- beta-Arabinosylcytosine
- beta-D-Arabinosylcytosine
Arabinosylcytosine Brand Names Mixture
- No information avaliable
Arabinosylcytosine Chemical_Formula
C9H13N3O5
Arabinosylcytosine RX_link
http://www.rxlist.com/cgi/generic3/cytarabine.htm
Arabinosylcytosine fda sheet
Arabinosylcytosine msds (material safety sheet)
Arabinosylcytosine Synthesis Reference
Krenitski, et al; Carbohydr.Res.; 97, 139-146(1981)
Arabinosylcytosine Molecular Weight
243.217 g/mol
Arabinosylcytosine Melting Point
212-213oC
Arabinosylcytosine H2O Solubility
Freely soluble
Arabinosylcytosine State
Solid
Arabinosylcytosine LogP
-2.712
Arabinosylcytosine Dosage Forms
Injectable solution
Arabinosylcytosine Indication
For the treatment of acute non-lymphocytic leukemia, acute lymphocytic leukemia and blast phase of chronic myelocytic leukemia.
Arabinosylcytosine Pharmacology
Cytarabine is an antineoplastic anti-metabolite used in the treatment of several forms of leukemia including acute myelogenous leukemia and meningeal leukemia. Anti-metabolites masquerade as purine or pyrimidine - which become the building blocks of DNA. They prevent these substances becoming incorporated in to DNA during the "S" phase (of the cell cycle), stopping normal development and division. Cytarabine is metabolized intracellularly into its active triphosphate form (cytosine arabinoside triphosphate). This metabolite then damages DNA by multiple mechanisms, including the inhibition of alpha-DNA polymerase, inhibition of DNA repair through an effect on beta-DNA polymerase, and incorporation into DNA. The latter mechanism is probably the most important. Cytotoxicity is highly specific for the S phase of the cell cycle.
Arabinosylcytosine Absorption
Less than 20% of the orally administered dose is absorbed from the gastrointestinal tract.
Arabinosylcytosine side effects and Toxicity
Cytarabine syndrome may develop - it is characterized by fever, myalgia, bone pain, occasionally chest pain, maculopapular rash, conjunctivitis, and malaise.
Arabinosylcytosine Patient Information
This medicine is a type of chemotherapy for treating cancers of the
blood and certain other cancers. This medicine interfers with the
way cancer cells grow, Take your doses on a regular scheduled time
and DO NOT take this medicine more often than directed by your health
care provider. Finish the full course prescribed by your health care
provider. DO NOT stop taking this medicine unless diredted to do so
by your health care provider. While taking this medicine, you make
get infection more easily. Call your doctor if you get a fever, chills,
or sore throat. Drink plenty of water with this medicine.
blood and certain other cancers. This medicine interfers with the
way cancer cells grow, Take your doses on a regular scheduled time
and DO NOT take this medicine more often than directed by your health
care provider. Finish the full course prescribed by your health care
provider. DO NOT stop taking this medicine unless diredted to do so
by your health care provider. While taking this medicine, you make
get infection more easily. Call your doctor if you get a fever, chills,
or sore throat. Drink plenty of water with this medicine.
Arabinosylcytosine Organisms Affected
Humans and other mammals
