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Antirex Brand names, Antirex Analogs

Antirex Brand Names Mixture

  • No information avaliable

Antirex Chemical_Formula


Antirex RX_link

Antirex fda sheet

Antirex FDA

Antirex msds (material safety sheet)

Antirex Synthesis Reference

No information avaliable

Antirex Molecular Weight

352.465 g/mol

Antirex Melting Point

No information avaliable

Antirex H2O Solubility

No information avaliable

Antirex State


Antirex LogP


Antirex Dosage Forms

Powder for solution

Antirex Indication

For the long-term intravenous treatment of primary pulmonary hypertension and pulmonary hypertension associated with the scleroderma spectrum of disease in NYHA Class III and Class IV patients who do not respond adequately to conventional therapy.

Antirex Pharmacology

Epoprostenol has two major pharmacological actions: (1) direct vasodilation of pulmonary and systemic arterial vascular beds, and (2) inhibition of platelet aggregation. In animals, the vasodilatory effects reduce right and left ventricular afterload and increase cardiac output and stroke volume. The effect of epoprostenol on heart rate in animals varies with dose. At low doses, there is vagally mediated brudycardia, but at higher doses, epoprostenol causes reflex tachycardia in response to direct vasodilation and hypotension. No major effects on cardiac conduction have been observed. Additional pharmacologic effects of epoprostenol in animals include bronchodilation, inhibition of gastric acid secretion, and decreased gastric emptying. No available chemical assay is sufficiently sensitive and specific to assess the in vivo human pharmacokinetics of epoprostenol.

Antirex Absorption

No information avaliable

Antirex side effects and Toxicity

Symptoms of overdose are extensions of its dose-limiting pharmacologic effects and include flushing, headache, hypotension, nausea, vomiting, and diarrhea. Most events were self-limiting and resolved with reduction or withholding of epoprostenol. Single intravenous doses at 10 and 50 mg/kg (2703 and 27,027 times the recommended acute phase human dose based on body surface area) were lethal to mice and rats, respectively. Symptoms of acute toxicity were hypoactivity, ataxia, loss of righting reflex, deep slow breathing, and hypothermia.

Antirex Patient Information

Antirex Organisms Affected

Humans and other mammals